Protein Info for CSW01_02075 in Vibrio cholerae E7946 ATCC 55056

Annotation: ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 597 transmembrane" amino acids 26 to 43 (18 residues), see Phobius details amino acids 49 to 74 (26 residues), see Phobius details amino acids 84 to 102 (19 residues), see Phobius details amino acids 109 to 128 (20 residues), see Phobius details amino acids 140 to 161 (22 residues), see Phobius details amino acids 184 to 203 (20 residues), see Phobius details amino acids 215 to 233 (19 residues), see Phobius details amino acids 239 to 257 (19 residues), see Phobius details amino acids 264 to 282 (19 residues), see Phobius details amino acids 356 to 380 (25 residues), see Phobius details amino acids 388 to 403 (16 residues), see Phobius details amino acids 409 to 427 (19 residues), see Phobius details amino acids 447 to 469 (23 residues), see Phobius details PF15864: PglL_A" amino acids 177 to 202 (26 residues), 44.6 bits, see alignment (E = 1.4e-15) PF04932: Wzy_C" amino acids 224 to 369 (146 residues), 63 bits, see alignment E=4.3e-21 PF11846: Wzy_C_2" amino acids 390 to 579 (190 residues), 224 bits, see alignment E=2.4e-70

Best Hits

KEGG orthology group: K13009, O-antigen polymerase (inferred from 100% identity to vch:VC0393)

Predicted SEED Role

"Lipid A core-O-antigen ligase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (597 amino acids)

>CSW01_02075 ligase (Vibrio cholerae E7946 ATCC 55056)
MNCMATLLLSGTRLEPHAPNLPLNKPFLFALAVVYLLAMHFFMPNPGGAGLALSFNTTVW
IATSITLAIGLYQLANNQALRYSKLTIGLWLSCALLTLPITYSNADWFHTLGRLVGLWAG
FTLFLVLQQFRFSNKHKQRLLWFILLGSVIEAVIGLIQYFWLEPGNPFGYDTEANRPYGI
FQQPNVMASFLATGLVLSGYLLARQPEKYDSRWSKIGILYATPLLTAPLLVVLASRTGWL
ASLLSIALVAPYLYRFASRRRFTLWLLAITLGICAGFTAMYGQGTSGFVANKADLESPRR
FTFPQTIDMIIEKPFTGYGYGKFEAQYLLYTARQHQLNSSYPAGLASMDHPHNELLYWGV
EGGLLPVMGILLAACFCALRIYAAKRGTRMAMLALFVPITLHAQLEYPFYHSAIHWITFI
ILIYWVDQRVARYRLASFTTLTKSLLRITSLVLPIVTSLYMVTALHTNYVLTQFEKSQPL
NPELLKNVTNPLVWQDRFDWDIYSTYLNIGLHEQKAELIQPYIDWSLQIIQHKPRPAFYS
NLILAYQGLGDTSRAQQIRREAEFLFPNQDFSTVQYHPSIKVNSATSDAEVPSAATP