Protein Info for CSW01_01715 in Vibrio cholerae E7946 ATCC 55056

Annotation: NADH pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 269 PF09297: Zn_ribbon_NUD" amino acids 108 to 136 (29 residues), 33.2 bits, see alignment (E = 3.4e-12) PF00293: NUDIX" amino acids 144 to 245 (102 residues), 74.7 bits, see alignment E=7.5e-25

Best Hits

Swiss-Prot: 100% identical to NUDC_VIBCH: NADH pyrophosphatase (nudC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03426, NAD+ diphosphatase [EC: 3.6.1.22] (inferred from 100% identity to vco:VC0395_A2733)

MetaCyc: 47% identical to RNA decapping hydrolase (Escherichia coli K-12 substr. MG1655)
NAD(+) diphosphatase. [EC: 3.6.1.22]; RXN0-7346 [EC: 3.6.1.22]

Predicted SEED Role

"NADH pyrophosphatase (EC 3.6.1.22)" in subsystem Nudix proteins (nucleoside triphosphate hydrolases) (EC 3.6.1.22)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (269 amino acids)

>CSW01_01715 NADH pyrophosphatase (Vibrio cholerae E7946 ATCC 55056)
MIRLQAIRRSRVEKSDGKNAYWCVVSGSDLWLVDGQIPYGSAEQWDLPQEKAILVDRYQN
SPVYWLNAADIEQDRPLTSLRELLGVDEALFLAASKAVQYGHMSQTIRFCPQCGGRNYLN
HQQLAMQCHDCRTLHYPRIFPCIIVAVRKQQQILLAQHPRHRNGMYTVIAGFVEVGETLE
QCVAREVLEETGIVVTNIRYFGSQPWAFPSSMMMAFLADYDTGELKPDYSELSDANWFGI
ENLPPVAPRGTIARALIEQTLADIAQDQA