Protein Info for CSW01_01620 in Vibrio cholerae E7946 ATCC 55056

Annotation: phosphatidylserine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00614: PLDc
  • amino acids 127 to 152 (26 residues), 24.2 bits, see alignment (E = 2.5e-09)
  • amino acids 352 to 374 (23 residues), 26.5 bits, see alignment (E = 4.8e-10)
• PF13091: PLDc_2
  • amino acids 251 to 402 (152 residues), 69.8 bits, E=2.1e-23

Best Hits

Swiss-Prot: 49% identical to PSS_ECOLI: CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA) from Escherichia coli (strain K12)

KEGG orthology group: K00998, phosphatidylserine synthase [EC: 2.7.8.8] (inferred from 100% identity to vcm:VCM66_0299)

MetaCyc: 49% identical to phosphatidylserine synthase (Escherichia coli K-12 substr. MG1655)
CDP-diacylglycerol--serine O-phosphatidyltransferase. [EC: 2.7.8.8]

Predicted SEED Role

"CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.8)

MetaCyc Pathways

• superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• phosphatidylserine and phosphatidylethanolamine biosynthesis I (2/2 steps found)
• cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) (3/4 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerophospholipid metabolism
• Glycine, serine and threonine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.8

Protein Sequence (446 amino acids)

>CSW01_01620 phosphatidylserine synthase (Vibrio cholerae E7946 ATCC 55056)
MIARRNPIEQLPAIAQDPDKFGVLLSAAEFRTHLVESIRQARKRIYLVALYLENDDAGRE
ILTELYAAKQRNPGLEIHICVDWHRAQRGLIGAAESEGNAAMYRDFAQQHEHCIPVYGIP
VRGREVFGVLHLKGFIIDDQVIYSGASLNNVYLQFHGRYRFDRYHTLENAELADSMVHFI
QQEMLAHPAVNNLACGSKPTTKEIKSDIRQFRASLAQANYQFAKQKVNEGQVAVTPLVGL
GRRRNRLNQSIIQLLASAKDEVFICTPYFNFPPSIAKEVKKALRRGVKVHIVIGDKTAND
FYIAPEEPFKTIGGLPYLYELNLRRFAKANEAHIASRKLSIHLWKHENHSFHLKGIWVDK
RYMLITGNNLNPRAWKLDLENAILIRDDYHHLTTKFEAEIDNILQHTQLICTYKQIEKPE
HYPEKVQRLVRRIMRLKADRVLKQIL