Protein Info for CSW01_01585 in Vibrio cholerae E7946 ATCC 55056

Annotation: NAD(P)H-flavin reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08030: NAD_binding_6
  • amino acids 109 to 164 (56 residues), 31.4 bits, E=1.9e-11
• PF00175: NAD_binding_1
  • amino acids 111 to 214 (104 residues), 88.9 bits, E=3.5e-29

Best Hits

Swiss-Prot: 72% identical to FRE_VIBHA: NAD(P)H-flavin reductase (fre) from Vibrio harveyi

KEGG orthology group: K05368, aquacobalamin reductase / NAD(P)H-flavin reductase [EC: 1.16.1.3 1.5.1.29] (inferred from 100% identity to vcm:VCM66_0296)

MetaCyc: 72% identical to FMN reductase (NADH) (Vibrio harveyi)
RXN-9510 [EC: 1.5.1.42]

Predicted SEED Role

"NAD(P)H-flavin reductase (EC 1.5.1.29) (EC 1.16.1.3)" in subsystem Ubiquinone Biosynthesis (EC 1.16.1.3, EC 1.5.1.29)

MetaCyc Pathways

• dibenzothiophene desulfurization (1/5 steps found)
• bacterial bioluminescence (2/8 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.16.1.3 or 1.5.1.29 or 1.5.1.42

Protein Sequence (236 amino acids)

>CSW01_01585 NAD(P)H-flavin reductase (Vibrio cholerae E7946 ATCC 55056)
MIIQCQVKSVQPLATHTYQILLQPEHAVAYQAGQYLMVVMGEKDKRPFSLASSPCRSNGE
LELHIGAADHSAFAHQVVEKFQQAHLNQTWVEVDVPHGNAALQESERPLLLIAGGTGFSY
VRSILDHCLSQGKTQPIYLYWGARDAAQLYALNELQELAKQHAHLQVVPVVEQAQDDWAG
KVGNVLQAINNDFASLEAFDIYIAGRFEMAGAAREQFTQNKQARRDRMFADAYAFI