Protein Info for CSW01_01550 in Vibrio cholerae E7946 ATCC 55056

Annotation: guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 497 PF02541: Ppx-GppA" amino acids 23 to 303 (281 residues), 304.5 bits, see alignment E=8.6e-95 PF21447: Ppx-GppA_III" amino acids 310 to 481 (172 residues), 135.1 bits, see alignment E=2.4e-43

Best Hits

Swiss-Prot: 100% identical to GPPA_VIBCH: Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (gppA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K01524, exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC: 3.6.1.11 3.6.1.40] (inferred from 100% identity to vco:VC0395_A2696)

MetaCyc: 57% identical to guanosine-5'-triphosphate,3'-diphosphate phosphatase (Escherichia coli K-12 substr. MG1655)
Guanosine-5'-triphosphate,3'-diphosphate diphosphatase. [EC: 3.6.1.40]

Predicted SEED Role

No annotation

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.11, 3.6.1.40

Use Curated BLAST to search for 3.6.1.11 or 3.6.1.40

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (497 amino acids)

>CSW01_01550 guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (Vibrio cholerae E7946 ATCC 55056)
MSQAVSSPLYAAIDLGSNSFHMLVVRHIDGSVQTMAKIKRKVRLAAGLDEHNALSLDAMQ
RGWDCLSLFAERLQDIPAENIRIVGTATLRTATNAGEFIAKANQILGHPIDVISGEEEAA
TIYKGVAHTSGGLGRRLVVDIGGASTELIIGEGFEAKALTSLKMGCVTWLERHFKDRQLT
ATNFNNAILAAKQMLDPILTQYTELGWNVCVGASGTVQALQEIMLAQGMDEVITLTKLKR
LQKQAMLADHLEELDIEGLTLERALVFPSGLSILIAIFESLNIEAMTLAGGALREGLVYE
MVQDLRQEDIRARTIRCVQTRYQIDSAYGDQVATLASKLLAQCGGEAWINEPQAEMLLRT
AAKLHEIGLTIDFKKGGEHSAYLLQHLDLPGYTRAQKHYLGEIVRRYREQLTSLPEQYAL
SGTSGKRVLRLLRLAVLLSHRRSPALEPMVELSAQEDKLTLTLDGEWLAKNPLTRTELEL
EANRQTDIGWPLSIECH