Protein Info for CSW01_01445 in Vibrio cholerae E7946 ATCC 55056

Annotation: lysine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03709: OKR_DC_1_N
  • amino acids 14 to 124 (111 residues), 106.5 bits, E=1.4e-34
• PF01276: OKR_DC_1
  • amino acids 130 to 545 (416 residues), 623.4 bits, E=2.7e-191
• PF03711: OKR_DC_1_C
  • amino acids 570 to 700 (131 residues), 153.3 bits, E=6.7e-49

Best Hits

Swiss-Prot: 75% identical to LDCI_ECO57: Inducible lysine decarboxylase (cadA) from Escherichia coli O157:H7

KEGG orthology group: K01582, lysine decarboxylase [EC: 4.1.1.18] (inferred from 87% identity to vsa:VSAL_I2491)

MetaCyc: 75% identical to lysine decarboxylase 1 (Escherichia coli K-12 substr. MG1655)
Lysine decarboxylase. [EC: 4.1.1.18]

Predicted SEED Role

"Lysine decarboxylase, inducible (EC 4.1.1.18)" in subsystem Lysine degradation (EC 4.1.1.18)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (13/17 steps found)
• cadaverine biosynthesis (1/1 steps found)
• aminopropylcadaverine biosynthesis (1/3 steps found)
• superpathway of polyamine biosynthesis I (4/8 steps found)
• bisucaberin biosynthesis (1/5 steps found)
• desferrioxamine B biosynthesis (1/5 steps found)
• desferrioxamine E biosynthesis (1/5 steps found)
• lupanine biosynthesis (1/5 steps found)
• L-lysine degradation X (1/6 steps found)
• L-lysine degradation I (1/7 steps found)
• superpathway of L-lysine degradation (9/43 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Lysine degradation

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.18

Protein Sequence (711 amino acids)

>CSW01_01445 lysine decarboxylase (Vibrio cholerae E7946 ATCC 55056)
MNIFAILNHMGVFFKEEPVRQLHAALEKAGYDVVYPVDDKDLIKMIEMNPRICGVLFDWD
KYSLELCERISKVNEKLPVHAFANEQSTLDISLTDLRLNVHFFEYALGMADDIAIKINQA
TQEYKDAIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQKSPVGSIFYDFYGPNTFKADV
SISMPELGSLLDHSGPHKEAEEYIARTFNADASYIVTNGTSTSNKIVGMFSAPAGSTVLV
DRNCHKSLTHLMMMTDVTPIYFRPTRNAYGILGGIPQNEFSREVIAEKVANTPGASAPSY
AVITNSTYDGLLYNTQFIKESLDCKHIHFDSAWVPYTNFNRIYEGKCGMSGEAMPGKVFY
ETQSTHKLLAAFSQASMIHVKGEFDRESFNEAFMMHTSTSPQYGIVASTETAAAMMRGNT
GRKLMQDSIDRAIRFRKEIKRLKGESEGWFFDVWQPENIETTECWKLDPNQDWHGFKNLD
DNHMYLDPIKITLLTPGMSKDGELEQSGIPASLVSKYLDEHGIVVEKTGPYNLLFLFSIG
IDKSKAMQLLRGLTEFKRGYDLNLTIRTMLPSLYREDPVFYEGMRIQELAQGIHDLTRKY
QLPELMYKAFDVLPEMKVTPHVAWQQELRGQTEEILLNEMVGRVSANMILPYPPGVPLVL
PGEMVTDSSRPVLDFLEMLCEIGAHYPGFETDIHGLYRQKDGSYTVKVLKD