Protein Info for CSW01_01440 in Vibrio cholerae E7946 ATCC 55056

Annotation: lysine:cadaverine antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 445 signal peptide" amino acids 7 to 8 (2 residues), see Phobius details transmembrane" amino acids 9 to 29 (21 residues), see Phobius details amino acids 41 to 59 (19 residues), see Phobius details amino acids 95 to 115 (21 residues), see Phobius details amino acids 121 to 140 (20 residues), see Phobius details amino acids 147 to 168 (22 residues), see Phobius details amino acids 188 to 209 (22 residues), see Phobius details amino acids 221 to 239 (19 residues), see Phobius details amino acids 267 to 291 (25 residues), see Phobius details amino acids 324 to 343 (20 residues), see Phobius details amino acids 355 to 374 (20 residues), see Phobius details amino acids 385 to 403 (19 residues), see Phobius details amino acids 409 to 425 (17 residues), see Phobius details PF13520: AA_permease_2" amino acids 8 to 422 (415 residues), 122 bits, see alignment E=3.2e-39 PF00324: AA_permease" amino acids 19 to 425 (407 residues), 87.2 bits, see alignment E=1e-28

Best Hits

Swiss-Prot: 69% identical to CADB_ECOLI: Probable cadaverine/lysine antiporter (cadB) from Escherichia coli (strain K12)

KEGG orthology group: K03757, cadaverine:lysine antiporter (inferred from 100% identity to vch:VC0280)

MetaCyc: 69% identical to lysine:cadaverine antiporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-68; TRANS-RXN0-212

Predicted SEED Role

"Lysine/cadaverine antiporter membrane protein CadB" in subsystem Lysine degradation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (445 amino acids)

>CSW01_01440 lysine:cadaverine antiporter (Vibrio cholerae E7946 ATCC 55056)
MSSNAKKIGLIACTGVVAGNMMGSGIALLPSTLASVGSISIYSWLICIVGALSLAFVFAR
LATKNPQEGGPIAYAGEVSPVFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPVLNNPI
PAGLATIASVWLFTLVNLLGGSWVSRLCTIGLVLILIPVVGTALFGWTHFDSALYSQNWN
VSAGSDGHAVITAVLICLWSFVGVESAAVSSGMVENPKRTVPLATMLGTGLAGLIYVLST
QMISGMFPASEVAASGAPFALATTALFGSWTAPFVSAFTALACFTSLGSWMMLVGEAGKR
AANDGNFPKVFGETDRNGVPKKGLLIASSMMTLLMLVLMFFSSETAHASDLFNQLTTDAV
LLTMLPYFYSSINLIRFEGMTTRNTFVMLFSGIASLFCMVALAGAEGSTLTATFIMSLII
LMFYSKKAGLDKYLETHPQQASAQF