Protein Info for CSW01_01370 in Vibrio cholerae E7946 ATCC 55056

Annotation: mechanosensitive ion channel family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 412 transmembrane" amino acids 25 to 48 (24 residues), see Phobius details amino acids 68 to 89 (22 residues), see Phobius details amino acids 103 to 125 (23 residues), see Phobius details amino acids 143 to 161 (19 residues), see Phobius details amino acids 167 to 192 (26 residues), see Phobius details PF00924: MS_channel_2nd" amino acids 185 to 253 (69 residues), 56.8 bits, see alignment E=2e-19 PF21082: MS_channel_3rd" amino acids 334 to 394 (61 residues), 29.6 bits, see alignment E=7.5e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to vch:VC0265)

Predicted SEED Role

"Small-conductance mechanosensitive channel"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (412 amino acids)

>CSW01_01370 mechanosensitive ion channel family protein (Vibrio cholerae E7946 ATCC 55056)
MLETLTLWLQKFDIEIERVIQLAEALGLIAAISIAIHLVLHRGVLLWLKRHTHHEQSVWR
NALFKEHLFSRVALLIQGVVIAVQTQLWLSPNTFAYDVLHTLTSLWIVVFGMLATYSVLN
VLELLISRTQVGKNLPTRGILQSIKLIVFIIAALFFTSILIGKSPVILLSGLGAMTAVFM
LVFKDPILGLVAGVQLSANKMLSVGDWLEMPKYGADGSVIDISLTTVKVQNWDKTITTIP
SYALISDSFKNWKGMQESGGRRIKRSILIDATSVHFLTEEEKQALKKAQLLEPYLVEKEQ
EISSYNQQKHWDLACRINGRRLTNIGSFRAYLERYLRTHPNIHQDMTLMVRQLAPTHDGI
SLEVYCFTSTTVWVEYERIQSDIFDHIYAVLPEFDLRVSQAPTGNDFRALRG