Protein Info for CSW01_01365 in Vibrio cholerae E7946 ATCC 55056

Annotation: MBL fold hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 455 PF00753: Lactamase_B" amino acids 32 to 212 (181 residues), 56.6 bits, see alignment E=8.6e-19 PF16661: Lactamase_B_6" amino acids 36 to 180 (145 residues), 30.7 bits, see alignment E=5e-11 PF12706: Lactamase_B_2" amino acids 43 to 105 (63 residues), 27.7 bits, see alignment E=4.9e-10 PF10996: Beta-Casp" amino acids 251 to 381 (131 residues), 110.1 bits, see alignment E=2.5e-35 PF07521: RMMBL" amino acids 395 to 454 (60 residues), 60 bits, see alignment E=4.7e-20

Best Hits

KEGG orthology group: K07576, metallo-beta-lactamase family protein (inferred from 100% identity to vco:VC0395_A2642)

Predicted SEED Role

"Metallo-beta-lactamase family protein, RNA-specific" in subsystem Bacterial RNA-metabolizing Zn-dependent hydrolases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (455 amino acids)

>CSW01_01365 MBL fold hydrolase (Vibrio cholerae E7946 ATCC 55056)
MLRRANHGKVAQNRRNNMEVVHHGGKASVTGSCHELRADGQALLIDCGLFQGADERPLAV
EFALGHVDALILTHAHIDHIGRLPWLLAAGLKQPIYSTAATAELVPLMLEDGLKLQLGMS
PKQSERVLTEVRRLLRVQDYQKWFAVQPKRADSLWVRFQPAGHILGSAYVEIRRPNGEVV
VFSGDLGPSHTPLLPDPQSPERADYLFIETTYGDKQHEDVQSRGQRLRAMIERSLTDGGA
ILIPAFSVGRTQELLFDIEQLIFSQQIDANLPIILDSPMAQRVTRSYRRFKQLWGREAKA
RLQMHRHPLAFEQCITVEDHRTHERLVNRLASTGEAAIVVAASGMCQGGRIMDYLKALLP
DKRTDLILAGFQAEGTLGRSIQSGQPSVWIEGTEVEVNAHIHTMSGYSAHADKADLLRFI
TGIPEKPKQVHLIHGEAPAKQAFAAELTQLGYSVL