Protein Info for CSW01_01265 in Vibrio cholerae E7946 ATCC 55056

Annotation: ADP-L-glycero-D-mannoheptose-6-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 314 TIGR02197: ADP-glyceromanno-heptose 6-epimerase" amino acids 2 to 313 (312 residues), 416.7 bits, see alignment E=2.9e-129 PF01370: Epimerase" amino acids 2 to 241 (240 residues), 148.7 bits, see alignment E=4e-47 PF01073: 3Beta_HSD" amino acids 3 to 225 (223 residues), 41.4 bits, see alignment E=1.8e-14 PF16363: GDP_Man_Dehyd" amino acids 3 to 260 (258 residues), 61.4 bits, see alignment E=2.1e-20

Best Hits

Swiss-Prot: 100% identical to HLDD_VIBC3: ADP-L-glycero-D-manno-heptose-6-epimerase (hldD) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K03274, ADP-L-glycero-D-manno-heptose 6-epimerase [EC: 5.1.3.20] (inferred from 100% identity to vco:VC0395_A2620)

MetaCyc: 74% identical to ADP-L-glycero-D-mannoheptose 6-epimerase (Escherichia coli K-12 substr. MG1655)
ADP-glyceromanno-heptose 6-epimerase. [EC: 5.1.3.20]

Predicted SEED Role

"ADP-L-glycero-D-manno-heptose-6-epimerase (EC 5.1.3.20)" in subsystem LOS core oligosaccharide biosynthesis (EC 5.1.3.20)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.20

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (314 amino acids)

>CSW01_01265 ADP-L-glycero-D-mannoheptose-6-epimerase (Vibrio cholerae E7946 ATCC 55056)
MIIVTGGAGMIGSNIIKALNERGITDILVVDHLKNGRKFKNLVDLQIADYMDRDDFLAQI
MAGDDFGFIDAIFHEGACSATTEWDGKYVMLNNYEYSKELLHYCLDREIPFLYASSAATY
GETDTFIEEPQYEGALNVYGYSKQQFDNYVRRLWLDAKQHDETLSQITGFRYFNVYGPRE
QHKGSMASVAFHLNNQMNAGENPKLFAGSENFKRDFVYVGDVAAVNLWFLDHGVSGIFNC
GTGKAESFNEVAKAVIAFHGRGEVETIPFPDHLKGAYQEFTEADLTKLRAAGCDVQFKSV
AEGVAEYMALINRK