Protein Info for CSW01_01065 in Vibrio cholerae E7946 ATCC 55056

Annotation: TonB-dependent siderophore receptor

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 718 signal peptide" amino acids 1 to 54 (54 residues), see Phobius details PF07715: Plug" amino acids 78 to 178 (101 residues), 74.9 bits, see alignment E=6.9e-25 TIGR01783: TonB-dependent siderophore receptor" amino acids 80 to 717 (638 residues), 358.7 bits, see alignment E=3.7e-111 PF00593: TonB_dep_Rec_b-barrel" amino acids 252 to 689 (438 residues), 217 bits, see alignment E=9.2e-68

Best Hits

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 100% identity to vch:VC0200)

Predicted SEED Role

"Ferrichrome-iron receptor" in subsystem Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (718 amino acids)

>CSW01_01065 TonB-dependent siderophore receptor (Vibrio cholerae E7946 ATCC 55056)
MRKINTNKNDSQIYSRGFIMRNIRPSQLGQYIRRALRLHFIPVVLVAAPSVMANTNQETE
QLETLVVTASALKVETPAQETPKALSIVTQEEIVARAPQKLDEALRYTSGVTAQPYGADN
DTDWLKVRGFDAATYQDGSRLFRDGYYTWLIEPYALERIEVLKGPASILYGEAPPGGVVN
AVQKKPTDIPQGEVGLQVGNDALRTLTLDISDYANQDGSVRYRLVALMKENDGQLNGTQT
SRNYLAPSLSIDISEQTRLTLLASFLEDSGVPTNPFFPAAGTLIDSNFGHIDPSTNLGQP
DYDKYERRQVSLGYLFEHDLNDVWALSQTFNYGDNDLYLRSSYAFSNDDPSKDTLTQGIV
FRDGSTESLSLDNKAVAKWDSARVENTLLMGLELQRHQTQGVELDNYSFGTINPFNPNYG
NFTPIDESSAADRTITKEQASLYAQYQIKLDQQWIGLIGGRMDWVDTENESQKNMQRKSR
SDAEFSFNAGLMYLASNGVSPYLSYSQSFDVLSTIDSAKGELYKPLKGEQTEVGVKYQPE
FYDGYINLAWFDITQQNALVTNPTTFVATQTGEMTAQGIEVESVGYVTDSLKLTASYTFT
DAKTDETGGKGTQQAGLIPKHQASAWLDYDAAQLGLQGWTFGSGVRYIGESKDNPRSSDR
TVPSVTLVDLMAGYEITENWQVQLNINNLFDREFVSGCDYWCYYGQSRSAVLSANYRW