Protein Info for CSW01_01000 in Vibrio cholerae E7946 ATCC 55056

Annotation: glutathione-disulfide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 TIGR01421: glutathione-disulfide reductase" amino acids 4 to 450 (447 residues), 712.7 bits, see alignment E=1.2e-218 PF07992: Pyr_redox_2" amino acids 6 to 319 (314 residues), 240.9 bits, see alignment E=6e-75 PF13738: Pyr_redox_3" amino acids 115 to 302 (188 residues), 65.1 bits, see alignment E=2e-21 PF00070: Pyr_redox" amino acids 169 to 246 (78 residues), 65.3 bits, see alignment E=1.8e-21 PF02852: Pyr_redox_dim" amino acids 340 to 450 (111 residues), 117 bits, see alignment E=1.5e-37

Best Hits

Swiss-Prot: 73% identical to GSHR_ECOLI: Glutathione reductase (gor) from Escherichia coli (strain K12)

KEGG orthology group: K00383, glutathione reductase (NADPH) [EC: 1.8.1.7] (inferred from 100% identity to vco:VC0395_A2568)

MetaCyc: 73% identical to glutathione reductase (NADPH) (Escherichia coli K-12 substr. MG1655)
Glutathione-disulfide reductase. [EC: 1.8.1.7]

Predicted SEED Role

"Glutathione reductase (EC 1.8.1.7)" in subsystem Glutathione: Redox cycle (EC 1.8.1.7)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>CSW01_01000 glutathione-disulfide reductase (Vibrio cholerae E7946 ATCC 55056)
MATHFDYLCIGGGSGGIASANRAAMYGAKVALIEAKDLGGTCVNVGCVPKKVMWHGAQIA
EAMHLYAEDYGFDVDVKNFNWAKLVESRQAYIGRIHQSYDRVLGNNKVHVIKGFAKFVDA
KTVEVNGELYTADHILIAVGGRPSIPNIPGAEYGIDSNGFFELSEQPKRVAVIGAGYIAV
EIAGVLNALGTETHLFCRKESPLRSFDPMIIETLVEVMNSEGPQLHTHSVPKQVVKEADG
SLTLHLENGQTYNVDTLIWAIGRHPATDAINLAATGVATNEQGYIKVDEFQNTNVAGIYC
VGDIMEGGIELTPVAVKAGRQLSERLFNNKLNAKMDYQLVPTVVFSHPPIGTIGLTEPQA
IAQYGAENVKVYKSSFTAMYTAVTSHRQPCKMKLVCAGPEETVVGLHGIGFAVDEMIQGF
GVAMKMGATKADFDSVVAIHPTGSEEFVTM