Protein Info for CSW01_00790 in Vibrio cholerae E7946 ATCC 55056

Annotation: vitamin B12 transporter BtuB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 611 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details TIGR01779: TonB-dependent vitamin B12 receptor" amino acids 1 to 611 (611 residues), 1004.9 bits, see alignment E=7e-307 PF07715: Plug" amino acids 43 to 148 (106 residues), 97.1 bits, see alignment E=8.5e-32 PF00593: TonB_dep_Rec_b-barrel" amino acids 205 to 585 (381 residues), 141 bits, see alignment E=1.1e-44

Best Hits

Swiss-Prot: 100% identical to BTUB_VIBCM: Vitamin B12 transporter BtuB (btuB) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K02014, iron complex outermembrane recepter protein (inferred from 100% identity to vch:VC0156)

Predicted SEED Role

"Outer membrane vitamin B12 receptor BtuB" in subsystem Coenzyme B12 biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (611 amino acids)

>CSW01_00790 vitamin B12 transporter BtuB (Vibrio cholerae E7946 ATCC 55056)
MQKSALAIALASLLTPISYLHANEAQPQETVVVTANRFEQKASSTLADVEIITRQDIEQT
QAKTLPELLRRLTGVQITQNGGRGQLASLFVRGTSSDQVLVLVDGIRFARAAKGAVDFNQ
IPLTYVDRIEYVRGARASLYGSEAIGGVINIITKARSQQQGTTVSAGLGSLDYQELSIAS
GVAIGEKGQMNVALGTESDKGYNVRPVPGVNDGDRHGFRSDNALLGYVHQFDESWSLFAN
ARAYENIYQYDNSYGTRDYKEAEKDDLSFTIGTQYQSERWVSELQLTTQKQKSWDYTQSK
GKYSDTSDNLEQRNIQWINRYLVNDVWTFAGGVDWRDESYIDKTADKEFDRSNTAAFAVV
AAEWQQWLLEASLRFDDNQEYGSQTTHNIALGYQFIPEFGVKASYGSAFKAPNLYQQYDP
SYGNVNLQPEDADSAELSFYGLFSGIKWSITGYDYKINNLIDYNSTTKNYQNVIGESNIK
GVEFTAEFATGIVQHQLSVDLKDADDSKGKTLQRRAEHMYKWNALVAFEQVDWSIGYQYV
GKRPDLDYNTYPTQNITLDAYSLVDTSVSYYVTDSTTISARIDNLLDKEYETANGYPAAE
RAYYLNIGYQF