Protein Info for CSW01_00620 in Vibrio cholerae E7946 ATCC 55056

Annotation: class I adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 843 PF12633: Adenyl_cycl_N" amino acids 5 to 199 (195 residues), 256.4 bits, see alignment E=2.2e-80 PF01295: Adenylate_cycl" amino acids 226 to 829 (604 residues), 877.4 bits, see alignment E=5.7e-268

Best Hits

Swiss-Prot: 56% identical to CYAA_YERIN: Adenylate cyclase (cya) from Yersinia intermedia

KEGG orthology group: K05851, adenylate cyclase, class 1 [EC: 4.6.1.1] (inferred from 100% identity to vch:VC0122)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (843 amino acids)

>CSW01_00620 class I adenylate cyclase (Vibrio cholerae E7946 ATCC 55056)
MQAYTQTLIHRLDKLNRQRIERALALMDLQSQRVFHLIPALFQFNHPLIPGYFSADTPFG
IHLFEANPIQQQFIDDAQLTLGEPLTPADNPAILGLYTMGSTSSIGQSTSSDLDIWVCVS
AQMSCEARDNLSSKCLLITDWAKSQGVEANFFIMNEERFRHNHSEALSGENCGSSQHLLL
LDEFYRSAVRLAGKRLLWQIVPPEMEECYDEYVHELCSNGYLNCNEWIDFGKLNRIPAEE
YFGANLWQLYKSIDSPYKSVLKAILLEAYSWEYPHTQLLSIDSKRRFFADEPDLYGMDSY
YQMLEKVTRYLVRIGDSTRLDLVRRCFYLKTHEKLSREPGVGSMPWRREALRELTSEWQW
SADLIAELDNRRHWKVEQVKVVHHALLDALMLSYRNLIQFARRNDITSAISPQDISILAR
KLYAAFEVLPGKVTLLNPQISPDLHEPDLSFIEVCAGRTNKPGWYLYKQPLQAQRLIGQP
YLEHNEYLSKLVAWAFFNGLITESTRLHAVVREAQLDIDKFYQMVSDLRNTFSLRKRRPT
MQALANPCEISQLAMFINFEHDPTSELSGKALKVDLKNIDIFSFGAEQKCLVGSVDLVYR
NSWQEVRTLHFEGQTAMLDALKTVLGKMHQDALPPESVDVFCYSKNLRGVMRNLVYQLLA
ECIDLRLKPMEQEKRRRFKALRMGDQMYGLFFERRGVSVQKLENSVDFYRSISTNKLKGS
PLLMLDRDQDYPLPAVVDSFASEGLVQFFFEDTEKGFNIYVLDEANRVEVYHQFNGEKDE
MIASVNSFYTSMLDDSNKLGAKSINFNLPQYYQIIHPEEGETYVVPYRNDSAVYSKPSQV
VNA