Protein Info for CSW01_00480 in Vibrio cholerae E7946 ATCC 55056

Annotation: MATE family efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 transmembrane" amino acids 20 to 45 (26 residues), see Phobius details amino acids 51 to 74 (24 residues), see Phobius details amino acids 94 to 116 (23 residues), see Phobius details amino acids 140 to 162 (23 residues), see Phobius details amino acids 171 to 193 (23 residues), see Phobius details amino acids 199 to 219 (21 residues), see Phobius details amino acids 251 to 271 (21 residues), see Phobius details amino acids 277 to 300 (24 residues), see Phobius details amino acids 321 to 343 (23 residues), see Phobius details amino acids 363 to 385 (23 residues), see Phobius details amino acids 396 to 413 (18 residues), see Phobius details amino acids 419 to 440 (22 residues), see Phobius details PF01554: MatE" amino acids 26 to 186 (161 residues), 92.3 bits, see alignment E=1.3e-30 amino acids 252 to 401 (150 residues), 59 bits, see alignment E=2.4e-20 TIGR00797: MATE efflux family protein" amino acids 26 to 420 (395 residues), 261.8 bits, see alignment E=5e-82

Best Hits

KEGG orthology group: K03327, multidrug resistance protein, MATE family (inferred from 100% identity to vch:VC0090)

Predicted SEED Role

"DNA-damage-inducible protein F"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (454 amino acids)

>CSW01_00480 MATE family efflux transporter (Vibrio cholerae E7946 ATCC 55056)
MFCVSLILQTLKQPNVHRQVLAIALPMVLSNITVPLLGLVDAAVIGHLEHAWYLGGVALG
STMISVTFWLLGFLRMSTTGLTAQAHGAQNSQQLARVLLQGSVIALGLAALFLLFHRPVA
ELIFHFSDASSEVKTYAEAYFYIRAWSAPAALLNFVLLGWLLGTQNARAPMWMVIITNLT
NIVLDLLLVLGLGLKVEGAAIASVIADYAGLLFGLLCVGRYWRQHQLPAPFSFIPSLTKE
LSRLVALNRDIFLRSLCLQAVFSFMTFQGAALGDDIVAANAVLMSFLMMISYGMDGFAYA
MEAMVGKAIGAKDDRQLRTAMISSTFWATMICLLLSLIFLGFGSDLIQMITNIPSVQATA
EHYLPWLVAMPLIAVWCFLLDGVFIGATKGKEMRNSMAVSAVAFFAIYGFMTHYGNHALW
LAMLSFMALRGFTLGATFYTQWRAGTFLPARFSI