Protein Info for CSW01_00405 in Vibrio cholerae E7946 ATCC 55056

Annotation: EamA family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 295 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 30 to 49 (20 residues), see Phobius details amino acids 56 to 77 (22 residues), see Phobius details amino acids 87 to 105 (19 residues), see Phobius details amino acids 112 to 130 (19 residues), see Phobius details amino acids 136 to 160 (25 residues), see Phobius details amino acids 173 to 192 (20 residues), see Phobius details amino acids 204 to 223 (20 residues), see Phobius details amino acids 233 to 254 (22 residues), see Phobius details amino acids 260 to 278 (19 residues), see Phobius details TIGR00950: carboxylate/amino acid/amine transporter" amino acids 11 to 274 (264 residues), 240.8 bits, see alignment E=8.6e-76 PF00892: EamA" amino acids 139 to 277 (139 residues), 36.6 bits, see alignment E=2.6e-13

Best Hits

Swiss-Prot: 55% identical to BIOP_PSEAE: Probable biotin transporter (PA3474) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A2439)

MetaCyc: 54% identical to biotin transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-240

Predicted SEED Role

"Putative acetate efflux pump, MadN"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (295 amino acids)

>CSW01_00405 EamA family transporter (Vibrio cholerae E7946 ATCC 55056)
MVYLSAVTLLWAFSFSLIGVYLAGQVDSWFAVWMRVALASLVFIPFLRFKGVPRALIAKL
MAIGGVQLGLMYCFYYQSFLLLSVPEVLLFTVFTPIYVTLIYDFLKGRFSPWYLVTAFIA
VLGAVFIKFAGINEHFVTGFLVVQGANLCFAIGQVGYKYVMEQESTELPQHTVFGYFYLG
ALLVASVAFLLLGNPEKLPTTSVQWSILVYLGLIASGLGYFAWNKGACMVNAGALAIMNN
ALVPAGLVVNILIWNREVDLVRLSLGGAIILGSLWINETWVKRRVERDYQRQGLL