Protein Info for CSW01_00390 in Vibrio cholerae E7946 ATCC 55056

Annotation: GGDEF domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 768 signal peptide" amino acids 1 to 34 (34 residues), see Phobius details transmembrane" amino acids 57 to 79 (23 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 213 to 333 (121 residues), 53 bits, see alignment E=3.8e-18 PF00989: PAS" amino acids 218 to 321 (104 residues), 30.6 bits, see alignment E=8.9e-11 PF13188: PAS_8" amino acids 218 to 263 (46 residues), 19.8 bits, see alignment 1.7e-07 PF08448: PAS_4" amino acids 223 to 329 (107 residues), 27.6 bits, see alignment E=8.8e-10 PF13426: PAS_9" amino acids 226 to 326 (101 residues), 45.8 bits, see alignment E=1.9e-15 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 335 to 497 (163 residues), 102.4 bits, see alignment E=2.2e-33 PF00990: GGDEF" amino acids 338 to 495 (158 residues), 113.1 bits, see alignment E=3.5e-36 PF00563: EAL" amino acids 520 to 753 (234 residues), 202.6 bits, see alignment E=1.9e-63

Best Hits

KEGG orthology group: None (inferred from 100% identity to vco:VC0395_A2442)

Predicted SEED Role

"Sensory box/GGDEF family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (768 amino acids)

>CSW01_00390 GGDEF domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MESDLSRLRHWYNKYALPLAVGLGCFWTANLVAQEPTLSSQPLDNLGTSRVPWDSELAAN
AMLWIVALVAIMVLSILTVRQYHYIQRLRTNQKLLESIFDQSTHYIGIFDLEGRIISCNG
KLQGLLYRHGESLLRPIWQHKGWEDSAVEHIQNYFSESVPQTRQFNAEIWHPELGAIVLE
CQFKPLPTREESQILLEAQDITWRKITEDKLFQREASLRHYYDQQPVMMLTLDERNHIQQ
VNHFAEQLLGYPADVMLGHHIRDFYQDEEVLTPRQMLLLPSRHASSVWRREVCYRHHSGE
TVWVRENIRPLVETGTLLIVGEDITETRQLADQLAYQARYDLLTHTLNRNQFELELAKAL
KETDSQLRTHAMLYLDLDQLKVLNDTAGHDAGDGAIQFCASMLEDVLPFKATLARMGGDE
FSVLLRDCTERDAVLVAQSIIHALSEVAFVWEHIRFNLTCSIGIRMIDHTATSPQMVHAQ
ADTACHAAKEEGRNRFNLYRQDDEDLRRRQLEMESVNLVHDALANERIELFAQRIVPLNQ
PDVLLHFEVLVRIKNAAGEYVSPGIFVPASERYNLAHRLDRKIVEQTFNWLEARPQVLDK
LGRVSINLSGNSIGNPDFVAFLLERLRDSRIPCSKVCFEITETAAMRNLNQAIKVLSQLK
SLGCVLALDDFGSGLSSFGYLQKLPVDIVKIDGIFVCDMDKNEMDRLMVRSIHELTKQMG
KSTVAEFVENQQILEALQQIGVDYAQGYLFSRPQPIADWVAEQLKEKA