Protein Info for CSW01_00170 in Vibrio cholerae E7946 ATCC 55056

Annotation: thiol:disulfide interchange protein DsbA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF13462: Thioredoxin_4" amino acids 38 to 189 (152 residues), 51.3 bits, see alignment E=2.3e-17 PF01323: DSBA" amino acids 40 to 189 (150 residues), 108.2 bits, see alignment E=7e-35

Best Hits

Swiss-Prot: 100% identical to DSBA_VIBCH: Thiol:disulfide interchange protein DsbA (dsbA) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03673, thiol:disulfide interchange protein DsbA (inferred from 100% identity to vco:VC0395_A2485)

Predicted SEED Role

"Periplasmic thiol:disulfide interchange protein DsbA" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (200 amino acids)

>CSW01_00170 thiol:disulfide interchange protein DsbA (Vibrio cholerae E7946 ATCC 55056)
MKKLFALVATLMLSVSAYAAQFKEGEHYQVLKTPASSSPVVNEFFSFYCPHCNTFEPIIA
QLKQQLPEGAKFQKNHVSFMGGNMGQAMSKAYATMIALEVEDKMVPVMFNRIHTLRKPPK
DEQELRQIFLDEGIDAAKFDAAYNGFAVDSMVRRFDKQFQDSGLTGVPAVVVNNRYLVQG
QSVKSLDEYFDLVNYLLTLK