Protein Info for CSW01_00020 in Vibrio cholerae E7946 ATCC 55056

Annotation: membrane protein insertase YidC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 342 to 366 (25 residues), see Phobius details amino acids 416 to 438 (23 residues), see Phobius details amino acids 461 to 479 (19 residues), see Phobius details amino acids 492 to 508 (17 residues), see Phobius details amino acids 512 to 532 (21 residues), see Phobius details TIGR03593: membrane protein insertase, YidC/Oxa1 family, N-terminal domain" amino acids 3 to 350 (348 residues), 373.4 bits, see alignment E=1.7e-115 PF14849: YidC_periplas" amino acids 67 to 341 (275 residues), 299.5 bits, see alignment E=3.8e-93 TIGR03592: membrane protein insertase, YidC/Oxa1 family" amino acids 351 to 530 (180 residues), 246.2 bits, see alignment E=2.7e-77 PF02096: 60KD_IMP" amino acids 352 to 531 (180 residues), 223.9 bits, see alignment E=1.2e-70

Best Hits

Swiss-Prot: 100% identical to YIDC_VIBCM: Membrane protein insertase YidC (yidC) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K03217, preprotein translocase subunit YidC (inferred from 100% identity to vco:VC0395_A2514)

Predicted SEED Role

"Inner membrane protein translocase component YidC, long form"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (541 amino acids)

>CSW01_00020 membrane protein insertase YidC (Vibrio cholerae E7946 ATCC 55056)
MDSQRNILLIALALVSFLLFQQWQVAKNPAPQATQQAQSTGAAPAPSFSDELDPTPAQNV
AAKAKTITVSTDVLTLSIDTLGGDVVSAKLNQYSEELNSPESFVLLQNTQGHQFIAQSGL
VGPQGIDVTSNNRPAYQVSADSFTLAEGQDELRIPMTYQANGIDYTKTFILKRGSYAVDV
VFDVANNSGSEATLGMYAHLRQNLLDSGGNLAMPTYRGGAYSTSDVRYKKYSFDDMKDRN
LSAPNDVTVNWVAMIQHYFASAWIPRDEPQAQLYSRVINNLGDMGIRTPNKTIANGDKAE
FEATLWVGPKLQDQMAATAPNLDLVVDYGWLWFIAKPLHWLLSVIQTFVGNWGVAIICLT
FIVRGAMYPLTKAQYTSMAKMRMLQPKLQAMRERIGDDRQRMSQEMMELYKKEKVNPLGG
CLPILLQMPIFIALYWALMESVELRHSPFFGWIHDLSAQDPYYILPLLMGASMFVIQKMS
PTTITDPMQQKIMTFMPVMFTFFFLWFPSGLVLYWLVSNIVTLIQQTLIYKALEKKGLHS
K