Protein Info for CCNA_03879 in Caulobacter crescentus NA1000

Annotation: uroporphyrinogen decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to DCUP_CAUVN: Uroporphyrinogen decarboxylase (hemE) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 100% identity to ccr:CC_3763)

Predicted SEED Role

"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)

MetaCyc Pathways

superpathway of heme b biosynthesis from glycine (7/8 steps found)
superpathway of heme b biosynthesis from glutamate (8/10 steps found)
heme b biosynthesis I (aerobic) (3/4 steps found)
heme b biosynthesis II (oxygen-independent) (3/4 steps found)
heme b biosynthesis V (aerobic) (3/4 steps found)
superpathway of heme b biosynthesis from uroporphyrinogen-III (4/6 steps found)
heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (2/9 steps found)
3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (2/9 steps found)
3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (2/9 steps found)
superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)

KEGG Metabolic Maps

Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.37

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8GW41 at UniProt or InterPro

Protein Sequence (351 amino acids)

>CCNA_03879 uroporphyrinogen decarboxylase (Caulobacter crescentus NA1000)
MTSSSPILKQTPKFLSALEGQSHANPPVWFMRQAGRYLPEYRAVRATAPDFISFCFDPEK
AAEVTLQPMRRFPFDASIVFADILLIPGALGQKVWFEAGEGPKLGDMPSVESMAEKAGEA
GKALSLVGETLTRVRSALDPDKALIGFAGAPWTVATYMIEKGSSDRSGARTFAYQNPETL
DALIQVLVDATIDYLAMQVDAGAQALKLFESWAEGLSEPLFDRLVTQPHIRIIEGLRARG
VTVPIIGFPRGAGTLVEDYAARTPVQGVALDTSASAKLGQTIQKTKTIQGALDPLLLRAG
GDALLKRVDEMLEQWNQGPYIFNLGHGILPDTPIAHVEAVLERVTGQKVGQ