Protein Info for CCNA_03838 in Caulobacter crescentus NA1000

Annotation: gluconate 2-dehydrogenase/glyoxylate reductase/hydroxypyruvate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00389: 2-Hacid_dh
  • amino acids 17 to 323 (307 residues), 108.1 bits, E=5.7e-35
• PF02826: 2-Hacid_dh_C
  • amino acids 113 to 292 (180 residues), 207.7 bits, E=1.8e-65
• PF03446: NAD_binding_2
  • amino acids 153 to 258 (106 residues), 26.5 bits, E=1.3e-09

Best Hits

Swiss-Prot: 47% identical to GYAR_THELN: Glyoxylate reductase (gyaR) from Thermococcus litoralis (strain ATCC 51850 / DSM 5473 / JCM 8560 / NS-C)

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_03838)

MetaCyc: 42% identical to glyoxylate reductase (Pyrococcus furiosus DSM 3638)
Glyoxylate reductase. [EC: 1.1.1.26]

Predicted SEED Role

"Glyoxylate reductase (EC 1.1.1.79) / Glyoxylate reductase (EC 1.1.1.26) / Hydroxypyruvate reductase (EC 1.1.1.81)" in subsystem Glycolate, glyoxylate interconversions or Photorespiration (oxidative C2 cycle) (EC 1.1.1.26, EC 1.1.1.79, EC 1.1.1.81)

MetaCyc Pathways

• L-serine biosynthesis II (2/4 steps found)
• D-xylose degradation IV (4/7 steps found)
• formaldehyde assimilation I (serine pathway) (8/13 steps found)
• photorespiration I (5/9 steps found)
• photorespiration III (5/9 steps found)
• photorespiration II (5/10 steps found)
• L-arabinose degradation IV (3/8 steps found)
• superpathway of pentose and pentitol degradation (12/42 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Glyoxylate and dicarboxylate metabolism
• Pyruvate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.26 or 1.1.1.79 or 1.1.1.81

Sequence Analysis Tools

See A0A0H3CE75 at UniProt or InterPro

Protein Sequence (328 amino acids)

>CCNA_03838 gluconate 2-dehydrogenase/glyoxylate reductase/hydroxypyruvate reductase (Caulobacter crescentus NA1000)
MAARKLKVIVTRKLPDPVETRMCELFDTELNVSDKPMTADELVDAMSRADVLVPTITDRI
DSRLLSRSGDRLKLIANFGAGVDNIDVATANARGIIVTNTPGVLTEDTADLTMTLIMAAS
RRIVEGAEVVKAGGFHGWSPTWMMGRRLWGKRLGIIGMGRIGQAVARRAKAFGMQVHYHN
RKPVSPRIAEELGCTYWESLDQMLARMDFVSVNCPHTPATYHLLSARRLKLLRPHAVVVN
TARGEVIDEGALANMLAKGEIAGAGLDVYEHEPAINPKLLKLPNVVLLPHMGSATVEGRI
DMGEKVIVNVKTFMDGHRPPDRVIPAML