Protein Info for CCNA_03393 in Caulobacter crescentus NA1000

Annotation: phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01162: phosphoribosylaminoimidazole carboxylase, catalytic subunit
  • amino acids 8 to 160 (153 residues), 217.2 bits, E=4e-69
• PF00731: AIRC
  • amino acids 8 to 155 (148 residues), 215 bits, E=1.7e-68

Best Hits

Swiss-Prot: 74% identical to PURE_BRUME: N5-carboxyaminoimidazole ribonucleotide mutase (purE) from Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

KEGG orthology group: K01588, 5-(carboxyamino)imidazole ribonucleotide mutase [EC: 5.4.99.18] (inferred from 100% identity to ccr:CC_3284)

MetaCyc: 66% identical to N5-carboxyaminoimidazole ribonucleotide mutase (Escherichia coli K-12 substr. MG1655)
5-(carboxyamino)imidazole ribonucleotide mutase. [EC: 5.4.99.18]

Predicted SEED Role

"Phosphoribosylaminoimidazole carboxylase catalytic subunit (EC 4.1.1.21)" in subsystem De Novo Purine Biosynthesis (EC 4.1.1.21)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.21

Use Curated BLAST to search for 4.1.1.21 or 5.4.99.18

Sequence Analysis Tools

See A0A0H3CC72 at UniProt or InterPro

Protein Sequence (163 amino acids)

>CCNA_03393 phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit (Caulobacter crescentus NA1000)
MPSTTPPVAIIMGSRSDWPTMKGAADALDNLGVAWEAKVVSAHRTPQRLFDFATGAEKAG
YKVIIAGAGGAAHLPGMAASMTNLPVLGVPVQSKALSGLDSLLSIVQMPGGVPVATLAIG
EAGAKNAGLLAAQILALSDTALAGRLAAFRAAQTESVAESVED