Protein Info for CCNA_03090 in Caulobacter crescentus NA1000
Annotation: acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 100% identical to ACCA_CAUVN: Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA) from Caulobacter vibrioides (strain NA1000 / CB15N)
KEGG orthology group: K01962, acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC: 6.4.1.2] (inferred from 100% identity to ccr:CC_2995)Predicted SEED Role
"Acetyl-coenzyme A carboxyl transferase alpha chain (EC 6.4.1.2)" in subsystem Fatty Acid Biosynthesis FASII (EC 6.4.1.2)
MetaCyc Pathways
- methylaspartate cycle (15/19 steps found)
- propanoyl CoA degradation I (3/3 steps found)
- 2-oxobutanoate degradation I (3/4 steps found)
- anaerobic energy metabolism (invertebrates, mitochondrial) (7/10 steps found)
- superpathway of anaerobic energy metabolism (invertebrates) (12/17 steps found)
- 3-hydroxypropanoate cycle (9/13 steps found)
- superpathway of the 3-hydroxypropanoate cycle (12/18 steps found)
- fatty acid biosynthesis initiation (type I) (1/3 steps found)
- 3-hydroxypropanoate/4-hydroxybutanate cycle (11/18 steps found)
- jadomycin biosynthesis (3/9 steps found)
- superpathway of L-methionine salvage and degradation (7/16 steps found)
- superpathway of mycolate biosynthesis (22/239 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 6.4.1.2
Use Curated BLAST to search for 6.4.1.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See B8H2N7 at UniProt or InterPro
Protein Sequence (320 amino acids)
>CCNA_03090 acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (Caulobacter crescentus NA1000) MAAHYLDFERPIADLESKIEELSRLSETAGPGAFDTEIQALRDRAQELRKEAYANLDAWQ KTMVARHPQRPHLRDYVAGLIDEFVELRGDRKFADDQAIVGGLGRFRGQPVVVMGHEKGH DTTTRLKHNFGMARPEGYRKAVRLMDMAERFNLPVITFVDTAGAYPGLGAEERGQAEAIA RSTERCLTLGVPMVATIVGEGGSGGAIALAGANRVLILEHSIYSVISPEGAASILWRDGA RAKDAATQMRITAQDLIKLGIVDRIVEEPAGGAHSDTEAAIQAVGDAVEDELKAMAAMSP AELKKQRSDRFYAIGRAGLQ