Protein Info for CCNA_02902 in Caulobacter crescentus NA1000

Annotation: xylan alpha-1,2-glucuronosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 711 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF03648: Glyco_hydro_67N" amino acids 25 to 141 (117 residues), 90.1 bits, see alignment E=2e-29 PF07488: Glyco_hydro_67M" amino acids 145 to 464 (320 residues), 506.8 bits, see alignment E=3.7e-156 PF07477: Glyco_hydro_67C" amino acids 466 to 689 (224 residues), 289.8 bits, see alignment E=2.1e-90

Best Hits

Swiss-Prot: 55% identical to AGUA_CELJU: Extracellular xylan exo-alpha-(1->2)-glucuronosidase (gla67A) from Cellvibrio japonicus (strain Ueda107)

KEGG orthology group: K01235, alpha-glucuronidase [EC: 3.2.1.139] (inferred from 100% identity to ccr:CC_2811)

Predicted SEED Role

"Alpha-galactosidase (EC 3.2.1.22)" in subsystem Fructooligosaccharides(FOS) and Raffinose Utilization or Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Melibiose Utilization (EC 3.2.1.22)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.1.139 or 3.2.1.22

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CDD7 at UniProt or InterPro

Protein Sequence (711 amino acids)

>CCNA_02902 xylan alpha-1,2-glucuronosidase (Caulobacter crescentus NA1000)
MRFLALVLGLLLLAPAARAEDGYDLWLRYKPVAESARVAYAARAAAIAPVAETPTLTVAR
AELERGLTGLVGQPASAAAGARDGVILLASGATPAITGLGLPLKTLGEEGYLIRTVTVGG
KATTVIAANRDIGVLYGVFRYLSLIQTGQSVDKLDIVSVPKVKLRMLNHWDNLDRHVERG
YSGQSIFDWWRLPGHVDPRMVDYARANASLGINGTVLNNVNAKADSLTAPFIAKAAALAD
TFRPYGIKVYLTARFSSPMEIGGLKTADPLDPAVRAFWKAKADEIYKTIPDFGGFLVKAN
SEGQPGPQDYGRTHVDGANMLADAVGPHGGVVFWRAFVYSHEQPEDRAKQGYNEFKPFDG
QFRDNVVIQVKNGAIDFQPREPFHPLFGAMPKTNLGMEFQITKEYLGFSTHLVYLGPMFE
ETLASDTMAKGKGSTVAKVIDGSLDGRKLTAMAGVANIGSDRNWSGSQFDQANWYVFGRL
AWDPEAGTQAIAQDWTRMTFGADPRLVTPVVSMMMGSREAAVDYMTPLGLHHQMGEGHHY
GPGPWVSGGPRADWTSVYYAKASETGIGFDRTATGSNATAQYAPAVGACYADLKCVDEKD
LLWFHHLPWDYRLKSGDTLWDGMVKRYGRGVSYVDGMNRTWAGLAPYVDARRHREVSDYL
KIQRAEAQWWRDASIAWFQTFAKRPLPAGEPAPNHTLEYYKALGFPFAPGI