Protein Info for CCNA_02725 in Caulobacter crescentus NA1000
Annotation: choline dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 48% identical to CHDH_RAT: Choline dehydrogenase, mitochondrial (Chdh) from Rattus norvegicus
KEGG orthology group: K00108, choline dehydrogenase [EC: 1.1.99.1] (inferred from 100% identity to ccr:CC_2642)MetaCyc: 48% identical to choline dehydrogenase (Homo sapiens)
Choline dehydrogenase. [EC: 1.1.99.1]
Predicted SEED Role
"Choline dehydrogenase (EC 1.1.99.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (EC 1.1.99.1)
MetaCyc Pathways
- choline-O-sulfate degradation (2/3 steps found)
- choline degradation I (1/2 steps found)
- glycine betaine biosynthesis I (Gram-negative bacteria) (1/2 steps found)
- glycine betaine biosynthesis II (Gram-positive bacteria) (1/2 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.99.1
Use Curated BLAST to search for 1.1.99.1
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0H3CBD0 at UniProt or InterPro
Protein Sequence (555 amino acids)
>CCNA_02725 choline dehydrogenase (Caulobacter crescentus NA1000) MASERFDYIVIGAGSAGCVLAARLTEDPNIKVLLLEAGGKNKSILVKMPAGVGQLIKDKG EQNWGFWTEAEPHLDNRKLWWPRGKGLGGSSAINGMIYIRGHARDYDQWRQMGLTGWSYS EVLPYFKRSETHHAGGDAYHGGSGPLHVSKGESDSPFYSTLVEAGRQAGHKTTKDFNGYQ QEGFGPYDLTIRDGQRWSAAMAYLNQALSRPNLTCVTEACTTRIILDKRRAVGVEYVVGK SREKQVAYADAEVLLSAGAVQSPQILQLSGIGAAEDLAPHGIAVAHESKGVGANLQDHLD VCVSWTAKNLKTAYSANKGLNKLGVGMNYMFFGKGLGRQQFLESGAFLKSRPDLDRPDLQ IHGVLAIMQDHGKVVVEKDGFTLHVCQLRPESRGKVGLRSADPFDDPTILGNYLATEEDR RAIREGVRIARETVAQAAFDPYRDAEYAPGADVKSDADLDAWIRSKAETIYHPVGTCRMG VAGDPMAVVDDQLRVQGVQGLRVIDASVMPTLIGGNTNAPTIMIAERAADLIRGKTPAAP LDVPVYEDGRAVAAE