Protein Info for CCNA_02721 in Caulobacter crescentus NA1000

Annotation: peptidase, M16 family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 950 976 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF00675: Peptidase_M16" amino acids 91 to 208 (118 residues), 98 bits, see alignment E=5.3e-32 PF05193: Peptidase_M16_C" amino acids 249 to 428 (180 residues), 57.7 bits, see alignment E=1.4e-19 amino acids 721 to 901 (181 residues), 93.1 bits, see alignment E=2e-30

Best Hits

KEGG orthology group: K07263, zinc protease [EC: 3.4.24.-] (inferred from 100% identity to ccr:CC_2638)

Predicted SEED Role

"putative zinc protease"

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CCX1 at UniProt or InterPro

Protein Sequence (976 amino acids)

>CCNA_02721 peptidase, M16 family (Caulobacter crescentus NA1000)
MISASRLAIVAAAGLSVAACSQLPKPSIPLLKKDAGQASAPKTPDAPALAGPKVTDLKPG
QWAQELSDVAPDPAWRFGVLPNGMRYALRKNATPPGQAALRLWIDAGSMMEADDQQGLAH
FLEHMAFNGSKNVPEGEMIKILERHGLAFGADTNASTSFDETIYQLDLPKTDDDTVDTSL
MLLREAAGELTIAPEAVDRERGVVLSEERTRDTPGYRVAIKTLSAQMEGQLPPKRIPIGK
TEVLKTAPAQRIRDFYEAYYRPERTVLVAVGDFDVDAMEAKIKGKFGDWVGKGPNGKDPD
VGPVAKRGPTAKMFVEAGAPWSIQMTWTRKPEGLLETKAVDERDTLENLGFAVLNRRLQA
VGRSAEPPFIAGGAFKGDQFGAVRVTTFGATAQPGRWREALTALDAEQRRAIQYGVRQDE
LDREIASLRAGLVAAAAGEATQRTPSLANQLVGTLGDGEVVTSPSQNLAAFDLFVKGLTA
ERVNAVLKSAFVGSGPLLVLAAPTAVEGGEPAILKAYEELKAQPVAPPIAPGVTVWPYSS
FGPTGKVAEQKEVSDLDAVLVRFDNGVRLTVKPTKFRDDQVIVKVRAGHGLLDMPSDKQS
PLWSGSAFIEGGLKQITAQDMERVLTGKIWNAQLGVEDDAFTLNGRTRPEDLSTELQVLA
AFATEPGWRPEAFNRIKTSYGTLHDQLQSTTGGVLGRDLGGLMHGGDQRWTFPSREQIAS
ASLDDLKAAVANPLAKGDLEVVIVGDTTVDKAIAAVADTFGALPARPGDPPLPGAEKAPF
PAPSKEPVIRTHKGRPDQAALFMTWRTDDLFSNLQRSRDVSVLGQVMQLRLTDELREKQG
ATYSPNATATASVVFDDWGYLAVSLEVPPEKLDGVVASIRKIAADLRDKPVSADELDRAK
KPRIDAIEKARVTNEYWVGALSGAHTDPRLLDATRSVIAGLSRVTPADVQKAAQTYLADE
KSWLLLVKPEAAAAAK