Protein Info for CCNA_02633 in Caulobacter crescentus NA1000

Annotation: membrane-bound glycosyl hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 786 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details PF07944: Beta-AFase-like_GH127_cat" amino acids 53 to 440 (388 residues), 451.5 bits, see alignment E=3.7e-139 PF20736: Glyco_hydro127M" amino acids 450 to 544 (95 residues), 93.1 bits, see alignment E=1.5e-30 PF20620: DUF6805" amino acids 659 to 782 (124 residues), 47.2 bits, see alignment E=4.2e-16

Best Hits

KEGG orthology group: K09955, hypothetical protein (inferred from 100% identity to ccs:CCNA_02633)

Predicted SEED Role

"Putative glycosyl hydrolase of unknown function (DUF1680)"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CA98 at UniProt or InterPro

Protein Sequence (786 amino acids)

>CCNA_02633 membrane-bound glycosyl hydrolase (Caulobacter crescentus NA1000)
MEQQAAATGLTRRTILLASSVLGLAGATAALAQPAVGAEVGGRVLATPVPARHVTLKPSI
FAQAQGANRAYLVSLQPDRLLHNFHLGAGLPVKAPVYGGWEAQSIAGHTLGHYLSACALQ
VANDGDPVLSQRLAYTVAQLARVQAAHGDGYVGGTTRWGQADPVGGKAVFEELRRGDIRA
NRFSLNDGWVPIYTWHKIHAGLLDAHRLAATPGALDVALGLAGYLATILEGLNDDQVQAI
LVAEHGGLCEAYAETYALTGDPRWLNIARRLRHRELVDPLAQGRDELAGLHANTQIPKII
GLARLYEVAGDPAEARTARFFHQTVTRRHSYAIGGNSDREHFGPPDAIATRLSETTCEAC
NSYNMLKLTRRLWSWAPDGALFDDYERAQLNHIMAHQRPSDGMFVYFMPMAAGGRRSYST
PEDSFWCCVGSGMESHAKHADSIWWRGGQTLYLNLFIASRLDLPGDDFAIDLDTAFPQSG
QVDLTVTRAPRGLREIALRLPAWCAAPRLSVNGAPTPIQTRGDGYARLSRRWKAGDRVTL
MLPMAVRAEPTPDDPNLVAFLSGPLVLAADLGPDERPFEQPVPALVGEGAAHALLQPAGA
ANPHVFSARTAQGGTARFSPFYALYDRRTAVYAPVFTPARWRAEGPAFLAAEQALIAAAA
RTVDVVYLGEQQPEVDHQVTARDSEIMQINGRSSRKLRPGGWLDMTLARRPGPLTLQLIY
WGQDTGQTATVRVDGAVIGQFQTPAAGQDGFFPLGLPLPPGAAPARVRIEAGAAPVMIYE
ARVMAG