Protein Info for CCNA_01863 in Caulobacter crescentus NA1000

Annotation: outer membrane efflux protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 478 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 13 to 474 (462 residues), 277 bits, see alignment E=1.5e-86 PF02321: OEP" amino acids 66 to 257 (192 residues), 60.3 bits, see alignment E=1.2e-20 amino acids 294 to 465 (172 residues), 86.9 bits, see alignment E=7.7e-29

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_01863)

Predicted SEED Role

"Outer membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C7L5 at UniProt or InterPro

Protein Sequence (478 amino acids)

>CCNA_01863 outer membrane efflux protein (Caulobacter crescentus NA1000)
MRTSFLPALSAVATAALLAGCAVGPDYVAPPAPSADAFMGQPAVAARAAAPAPADAWWRG
FNDPVLDRLVDRALAQNLDLAQAAARVTQARAGLGAATAALLPSASIQAQGVANHASTQT
PTGRLLAATPGFDRDGSLYEGNLVAGWELDVFGGTRRDREAALARYDAAKAGVAAARLAV
AAQTADTYILVRGLQERLAVARGQVETQARLVDTVRLQYDHGAAADLQLQQAQGALAQTR
AGIPVLEEGLEAALNAMDVIQGAQPGTYRAELVTTTAIPVAPGLTEAGGPAGLLRRRPDL
VVAEQRLRASNAEVGSALSQYFPKVSLSGLVGTATTSSATLFEGSATQAQGVLGLRWRLF
DFGRVGAEVKAARGRKAEALAAYQQAVLRASEDVENAFVSLVKREVQARALSGGEASLAK
ARTASQVAYEAGAVSLVEVLDADARLLAVRDARAQARTEAARAAIRSFQALGGGWSAS