Protein Info for CCNA_01775 in Caulobacter crescentus NA1000

Annotation: phosphoribosylformylglycinamidine cyclo-ligase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 64% identical to PUR5_OCHA4: Phosphoribosylformylglycinamidine cyclo-ligase (purM) from Ochrobactrum anthropi (strain ATCC 49188 / DSM 6882 / JCM 21032 / NBRC 15819 / NCTC 12168)

KEGG orthology group: K01933, phosphoribosylformylglycinamidine cyclo-ligase [EC: 6.3.3.1] (inferred from 100% identity to ccs:CCNA_01775)

Predicted SEED Role

"Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1)" in subsystem De Novo Purine Biosynthesis (EC 6.3.3.1)

MetaCyc Pathways

superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
superpathway of 5-aminoimidazole ribonucleotide biosynthesis (5/6 steps found)
5-aminoimidazole ribonucleotide biosynthesis II (4/5 steps found)

KEGG Metabolic Maps

Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.3.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C924 at UniProt or InterPro

Protein Sequence (341 amino acids)

>CCNA_01775 phosphoribosylformylglycinamidine cyclo-ligase (Caulobacter crescentus NA1000)
MSDLPNGLTYAQAGVDIDAGNALVDAIKPLAKATRRPGAEASLGGFGALFDLKAAGYDDP
LLVTTTDGVGTKLRIAIDTGMHATVGIDLVAMCVNDLLAQGAEPLMFLDYFATGKLDVET
AKSVVAGIAEGCKISGSALVGGETAEMPGMYADGEYDLAGFSVGAVNRDAVLPKLDQQRA
GDIIIGLGSSGPHSNGYSLVRRVVERSGLAWDAPCPFEDGKTLAEALMAPTRIYVKSLLP
LLKSGRVKGGAHITGGGLIENPPRAIAEGLAAEFNWNSWAMPPVFDWLAQTGGITEHEMR
RTFNCGVGFIIIVAQADAEPVLAALLNAGEDAFICGQLVKA