Protein Info for CCNA_01624 in Caulobacter crescentus NA1000

Annotation: orotate phosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01367: orotate phosphoribosyltransferase
  • amino acids 5 to 190 (186 residues), 291.7 bits, E=1e-91
• PF00156: Pribosyltran
  • amino acids 45 to 153 (109 residues), 42.7 bits, E=1.8e-15

Best Hits

Swiss-Prot: 100% identical to PYRE_CAUVC: Orotate phosphoribosyltransferase (pyrE) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K00762, orotate phosphoribosyltransferase [EC: 2.4.2.10] (inferred from 100% identity to ccr:CC_1555)

Predicted SEED Role

"Orotate phosphoribosyltransferase (EC 2.4.2.10)" in subsystem De Novo Pyrimidine Synthesis (EC 2.4.2.10)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• UMP biosynthesis II (6/6 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• UMP biosynthesis I (5/6 steps found)
• UMP biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Drug metabolism - other enzymes
• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.10

Sequence Analysis Tools

See B8H621 at UniProt or InterPro

Protein Sequence (194 amino acids)

>CCNA_01624 orotate phosphoribosyltransferase (Caulobacter crescentus NA1000)
MTNDDVLDEFRAAGALREGHFVLSSGLHSPVFLQKNLVFMRPERCERLCKALAQKIIATV
GQVDVAVSPAVGGIIPGYETARHLNVPSIYVEREGGGFKFRRGFHLEPGQKVVMVEDIVT
TGLSSRECIQAIKDAGGDVVAAACIVDRSGGKADVGVPLIALASLEVPAYPADALPPELA
AIPIEDPGSRRLKG