Protein Info for CCNA_00659 in Caulobacter crescentus NA1000

Annotation: type I restriction-modification system restriction subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 964 PF04313: HSDR_N" amino acids 118 to 214 (97 residues), 60.7 bits, see alignment E=4.5e-20 PF04851: ResIII" amino acids 277 to 440 (164 residues), 47.6 bits, see alignment E=4.4e-16 PF18766: SWI2_SNF2" amino acids 280 to 519 (240 residues), 70.3 bits, see alignment E=4.8e-23 PF00270: DEAD" amino acids 297 to 486 (190 residues), 26.3 bits, see alignment E=1.5e-09 PF22679: T1R_D3-like" amino acids 648 to 712 (65 residues), 36.2 bits, see alignment 2.1e-12

Best Hits

KEGG orthology group: K01153, type I restriction enzyme, R subunit [EC: 3.1.21.3] (inferred from 100% identity to ccr:CC_0623)

Predicted SEED Role

"Type I restriction-modification system, restriction subunit R (EC 3.1.21.3)" in subsystem Restriction-Modification System (EC 3.1.21.3)

Isozymes

Compare fitness of predicted isozymes for: 3.1.21.3

Use Curated BLAST to search for 3.1.21.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C5A5 at UniProt or InterPro

Protein Sequence (964 amino acids)

>CCNA_00659 type I restriction-modification system restriction subunit (Caulobacter crescentus NA1000)
MSLHKEIRFEDEICAHLAANGWLYDGAAGDRHDRTRALYVEDLVAWVQDSQPEAWDGLSR
ANGAAAAQVLADRVRKSLDERGVLDVLRNGVELVGARGRIQMAQFKPAMGMNPEIVRRYE
ANRLRVARQVKYAVGNENCLDLVLYLNGLPVATAELKSDFTQSVEDAINQYRFDREPRPK
GGREEPLLAFPGGALVHFAVSNSEVAMTTKLQGRDTFFLPFNKGDHGGKGNPLNPNGHRT
AYLWEEIWARDSWLEILGRYMVTKRDAKKRITSVVFPRYHQLDATRKLAAQVLAEGAGGK
FLIQHSAGSGKTNSIAWSAHILSELHDAADNKLFSSVIVVSDRNVIDTQLQEALFDFQRT
AGVVATIKSESGSKSGQLAEALAAGKKVIVCTIQTFPFALEAVREQAATQGKAFAVIADE
AHSSQTGEAAGKLKQMLSDAEIAELADGGEIDFETQLTANMAGRAASDKSITYVAFTATP
KAKTLQLFGRPDADGLPAPFHVYSMRQAIEEGFILDVLKNYTPYSLAFKLANDGQEWDER
EVERDTALKGIMRWVRLHPYNIAQKVQIVVEHYRENVQPLLDGKAKAMVVLGSRQEAVRW
SVAINAYIRKMGYPLGTLVAFSGEVNDDELGAVSETSAALNPGLNGRDIRDAFKAENFHF
LLVANKFQTGFDQPLLCGMYVDRRLAGIQAVQTLSRLNRAHPGKDTTYILDFCNSAEDIL
TAFRTYYETAELEAATDPNLIYDLRAKLDAAGHYDDHEIERVVRVELDPKAKQGDLIAAL
EPVADRLVKAFAAAKQAWVTAKAQDDERAAAEALDHMNALDLFKGDMAAFQRLYSFLSQI
FDYGNTEIEKRSIFFRRLLPLLEFGRERPGVDLSGLRLTHHALKTKGQQDLLYGTGEAPK
LSGMAEVGSGGLHEKEKARLDEIIAKLNDLFEGEITEENCTSSEVLRQPGCGFSGGLASS
GFDI