Protein Info for CA265_RS25460 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: methylmalonyl-CoA mutase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00641: methylmalonyl-CoA mutase N-terminal domain
  • amino acids 6 to 515 (510 residues), 757.3 bits, E=3.4e-232
• PF01642: MM_CoA_mutase
  • amino acids 7 to 513 (507 residues), 761.8 bits, E=1.7e-233

Best Hits

KEGG orthology group: K01848, methylmalonyl-CoA mutase, N-terminal domain [EC: 5.4.99.2] (inferred from 83% identity to phe:Phep_3607)

MetaCyc: 54% identical to methylmalonyl-CoA mutase alpha subunit (Metallosphaera sedula)
Methylmalonyl-CoA mutase. [EC: 5.4.99.2]

Predicted SEED Role

"Methylmalonyl-CoA mutase (EC 5.4.99.2)" in subsystem Propionyl-CoA to Succinyl-CoA Module or Serine-glyoxylate cycle (EC 5.4.99.2)

MetaCyc Pathways

• propanoyl CoA degradation I (3/3 steps found)
• 2-oxobutanoate degradation I (3/4 steps found)
• pyruvate fermentation to propanoate I (4/7 steps found)
• conversion of succinate to propanoate (1/3 steps found)
• anaerobic energy metabolism (invertebrates, mitochondrial) (6/10 steps found)
• superpathway of anaerobic energy metabolism (invertebrates) (10/17 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (7/13 steps found)
• 3-hydroxypropanoate cycle (7/13 steps found)
• superpathway of L-methionine salvage and degradation (9/16 steps found)
• methylaspartate cycle (11/19 steps found)
• 3-hydroxypropanoate/4-hydroxybutanate cycle (10/18 steps found)
• L-glutamate degradation VIII (to propanoate) (4/11 steps found)
• superpathway of the 3-hydroxypropanoate cycle (7/18 steps found)
• crotonyl-CoA/ethylmalonyl-CoA/hydroxybutyryl-CoA cycle (engineered) (3/14 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 5.4.99.2

Use Curated BLAST to search for 5.4.99.2

Sequence Analysis Tools

See A0A1X9ZC20 at UniProt or InterPro

Protein Sequence (515 amino acids)

>CA265_RS25460 methylmalonyl-CoA mutase (Pedobacter sp. GW460-11-11-14-LB5)
MSEKKHTTTSGIEIKALYTKAKPMEELPGEFPFTRGIQKDMYRGRLWTMRQYAGFSTAEE
SNKRYHYLLAQGTTGLSVAFDLPTQIGYDSDHEMADGEVGKVGVAIDSLKDIEILFDGIQ
LKDITTSMTINATASILLAMYIALAKKQGADLKQISGTIQNDILKEYAARGTYIYPPKQS
MRLITDIFEFCSKEVPKWNTISISGYHIREAGSTAVQELAFTLANGKTYLKAALDKGLDI
NVFAKRLSFFFNCHNNFFEEIAKFRAARRMWAKITKDLGATDEKAQMLRFHTQTGGSTLT
AQQPLNNVIRVSNQAMAAVLGGTQSLHTNGYDEALSLPTESAAKIALRTQQIIAFESGVT
DTVDPLAGSFFVENLTDEVETAAWAYIDRIDAMGGSVNAIESDYMQNEIAGASYQYQKEI
ESGERISVGVNKFTQEEEGLTEVFNIDDSIRKLQSEKLEILKTTRDNDAVEKALQSLHEA
AKGETNLMPLIIDAVEKYATLGEIADVFRGTFGVY