Protein Info for CA265_RS25285 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: dihydropteroate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01496: dihydropteroate synthase
  • amino acids 26 to 280 (255 residues), 309.1 bits, E=1.4e-96
• PF00809: Pterin_bind
  • amino acids 28 to 267 (240 residues), 250.4 bits, E=1e-78

Best Hits

Swiss-Prot: 39% identical to DHPS_CLOB8: Dihydropteroate synthase (Cbei_0206) from Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052)

KEGG orthology group: K00796, dihydropteroate synthase [EC: 2.5.1.15] (inferred from 59% identity to phe:Phep_3663)

Predicted SEED Role

"Dihydropteroate synthase (EC 2.5.1.15)" in subsystem Folate Biosynthesis (EC 2.5.1.15)

MetaCyc Pathways

• superpathway of tetrahydrofolate biosynthesis and salvage (10/12 steps found)
• tetrahydrofolate biosynthesis I (3/3 steps found)
• superpathway of tetrahydrofolate biosynthesis (8/10 steps found)
• tetrahydrofolate biosynthesis II (2/3 steps found)
• superpathway of chorismate metabolism (35/59 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.5.1.15

Sequence Analysis Tools

See A0A1X9ZC38 at UniProt or InterPro

Protein Sequence (283 amino acids)

>CA265_RS25285 dihydropteroate synthase (Pedobacter sp. GW460-11-11-14-LB5)
MAEKNFFEPKQSLNIKGKLIDLSSPKVMGILNITPDSFYSNSRTKSIDEALTKAAQFLHE
GATFIDVGGYSSRPGAKDISAAEEADRLLPVVESLAAAFPEAVISIDTFRAKVAQETILA
GAHIINDISSGDMDELMFETVAKLQVPYMIMHMQGTPQNMQQNPVYKNVLLEVIDYLAKK
VAALKALHIHDVIIDPGFGFGKTTEHNYELLKQMEAFKIFKLPILVGFSRKGMIYKTLGT
SAAEALNGTSVLNTIALQKGAGILRVHDVKEAVECVRLVAKLG