Protein Info for CA265_RS21345 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 515 transmembrane" amino acids 9 to 33 (25 residues), see Phobius details amino acids 48 to 69 (22 residues), see Phobius details amino acids 77 to 96 (20 residues), see Phobius details amino acids 102 to 124 (23 residues), see Phobius details amino acids 134 to 157 (24 residues), see Phobius details amino acids 165 to 185 (21 residues), see Phobius details amino acids 197 to 216 (20 residues), see Phobius details amino acids 228 to 246 (19 residues), see Phobius details amino acids 266 to 290 (25 residues), see Phobius details amino acids 305 to 324 (20 residues), see Phobius details amino acids 331 to 349 (19 residues), see Phobius details amino acids 361 to 383 (23 residues), see Phobius details amino acids 404 to 423 (20 residues), see Phobius details amino acids 484 to 501 (18 residues), see Phobius details TIGR00711: drug resistance MFS transporter, drug:H+ antiporter-2 (14 Spanner) (DHA2) family" amino acids 11 to 496 (486 residues), 414.3 bits, see alignment E=3.5e-128 PF07690: MFS_1" amino acids 17 to 409 (393 residues), 189.6 bits, see alignment E=7.9e-60 PF00083: Sugar_tr" amino acids 47 to 189 (143 residues), 43.6 bits, see alignment E=2e-15

Best Hits

KEGG orthology group: K03446, MFS transporter, DHA2 family, multidrug resistance protein B (inferred from 86% identity to phe:Phep_4262)

Predicted SEED Role

"Inner membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9ZAR7 at UniProt or InterPro

Protein Sequence (515 amino acids)

>CA265_RS21345 MFS transporter (Pedobacter sp. GW460-11-11-14-LB5)
MAEVGLKKWIITFTVITASLLELIDTTIVNVAIPQIQGNLGATLEDVAWLSTGYAVANVI
VLPMSGWLGNRFGRKNYFLTSIIVFTLVSFLCGNATSLNELILFRIIQGLAGGGLISTAQ
AILIETWPREDVGIATALFGLGAVVGPTVGPTIGGYILEISSWPWIFYVNIPVGILAAYC
TYTFVRATPKSGQGQPVDWWGIALLAIAVGSLQTLLEKGESEDWFATPYITALAVASVFG
LLLFIWREMTTDHPIVNFKIMRHRSFSVGMFTSFILGFGLYGSVFVFPVFCQNLLGFSPL
QTGEILFPGGLCTIVMMPFIGIMLKKGVPAQIMATFGMLAFFIFCWMLSNSTLQSGTGDF
FWPLVIRGVGMALLFVPLTTLAIQDLKGPEIGQGSGLNNMMRQLGGSFGIAALTTLIHIR
SGFHRSVLLSNVNDYNQPFVDRFNGLIKGFMAKGQTLFDAKIMAAKAMEGIVTRQTMLLT
YDDAYWVAGLIMLFSIPLLYLQKFKKNANIPADVH