Protein Info for CA265_RS17530 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: 2-oxoglutarate dehydrogenase E1 component

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 931 PF16078: 2-oxogl_dehyd_N" amino acids 5 to 43 (39 residues), 57 bits, see alignment (E = 2.3e-19) TIGR00239: oxoglutarate dehydrogenase (succinyl-transferring), E1 component" amino acids 6 to 907 (902 residues), 1078.3 bits, see alignment E=0 PF00676: E1_dh" amino acids 183 to 497 (315 residues), 164.5 bits, see alignment E=5.9e-52 PF02779: Transket_pyr" amino acids 572 to 764 (193 residues), 162.2 bits, see alignment E=2e-51 PF16870: OxoGdeHyase_C" amino acids 769 to 908 (140 residues), 147.7 bits, see alignment E=4.4e-47

Best Hits

KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 86% identity to phe:Phep_3716)

Predicted SEED Role

"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.4.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z820 at UniProt or InterPro

Protein Sequence (931 amino acids)

>CA265_RS17530 2-oxoglutarate dehydrogenase E1 component (Pedobacter sp. GW460-11-11-14-LB5)
MDKLSYLNGANAEYIESLYQSYQQDPESVEFGWQKFFEGFDFGRGSEAPTVTAETPEQFL
KEVNVLNLIDGYRSRGHLFTHTNPVRERRKHLPTLDLANFGLSDADLETVFNSGVEIGIG
AAKLKDIVAFLKQTYAHSIGAEYKFLRTPEVLNWIQQKMESARNTPNFSIDEKKRILRKL
NEAVSFENFLGTKFLGQKRFSLEGAEALIPALDSVIEKGAELGIEEFVIGMAHRGRLNVL
ANIMQKTYKDIFAEFEGKSYNPDTPFGGDVKYHLGYSTDVTTVSGKSVHLSLCPNPSHLE
TVDGVVEGMSRSKIDFKYGGDNSRLAPILIHGDASVAGQGIVYEVIQMAGLEGYKTGGTI
HLVINNQIGFTTNYKDARTSTYCTDIAKVTLSPVFHVNGDDPEALVYAINLAMEYRQKYK
NDVFIDILCYRRFGHNESDEPKFTQPLLYKTIEKHPNPREIYIDQLTKEGKLEAGLAKEM
EKDFRGILQERLNEAKEFVAGNAEVKFGGAWADLRMATPKDFESSPVTAVKKSTLLEIGK
RITALPSNKKFFKKIEKLFAERGKMVNETNVFDWAMGEQLAYGTLLSEGKRVRLSGQDVE
RGTFSHRHAVLTLEDSEEEYVPLANISDQQAAFDIYNSHLSEYGVLGFEYGYAMANPNAL
TIWEAQFGDFFNGAQIVVDQYIASAETKWQRENGLVMLLPHGYEGQGPEHSSARIERFME
LCADYNMQVTNCTTPANFFHVLRRQFKRDFRKPLVVFTPKSLLRHPACVSKLEEFTEGGF
KEVIDDVNVKVADVTRIVFCSGKIYYELLEKQQADKLKHVALVRVEQLYPTPVDQMEAIQ
KKYKNAKEIFWVQEEPENMGAWPYLFRRLYKTALKGIDVISRRESSSTATGFAKQHSNQQ
AYILAKALEISVTEDVKDIAKKATKKLVQID