Protein Info for CA265_RS16380 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: efflux transporter periplasmic adaptor subunit

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 446 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details TIGR01730: efflux transporter, RND family, MFP subunit" amino acids 34 to 347 (314 residues), 130 bits, see alignment E=4.7e-42 PF16576: HlyD_D23" amino acids 46 to 278 (233 residues), 69 bits, see alignment E=9.2e-23 PF13533: Biotin_lipoyl_2" amino acids 60 to 95 (36 residues), 34.8 bits, see alignment 2.9e-12 PF13437: HlyD_3" amino acids 197 to 318 (122 residues), 52.8 bits, see alignment E=1.4e-17

Best Hits

KEGG orthology group: K02005, HlyD family secretion protein (inferred from 72% identity to phe:Phep_0663)

Predicted SEED Role

"Macrolide-specific efflux protein MacA" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z7B2 at UniProt or InterPro

Protein Sequence (446 amino acids)

>CA265_RS16380 efflux transporter periplasmic adaptor subunit (Pedobacter sp. GW460-11-11-14-LB5)
MKLKHIIITVVAIVALLVILKLAGVIGGDKTEKVTTEKASDKTVVETVTASGKIQPETEV
KLSSEVSGEVVELKVKEGDIVKAGQLLCKVRPDVLQSGYERTVASFNAQKASVASAQQQL
VQNQANFVNADATYKRNVELFNKKVISASEFDAAKAAYLTAKANLASAKESVIGAKFTLE
QTGANVKEAGANLAKTTIYAPVDGVVSKLSIELGDRILGTSQMAGTEIMRISNLSSMEVN
VDVNENDITRVKVGDKASIEVDAFSDKKFRGEVTEIASSSTAVGTAVSTSVDQVTNFSVK
IRITEELAGKQQSIFRPGMSATVDIESESLTGLAIPIQAVFTDNAKSADASQNQGNQANT
DKQKSKLTDKKVKQYIYAYDAKTKKVKKTEVTTGIQNDQFIIVKSGVKTGEEIVTGPYSA
IQNKLKDGMIVEKTSKDQLFNKDAKK