Protein Info for CA265_RS16240 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: alpha-mannosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 762 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details TIGR01180: putative alpha-1,2-mannosidase" amino acids 6 to 745 (740 residues), 786.1 bits, see alignment E=1.5e-240 PF17678: Glyco_hydro_92N" amino acids 30 to 258 (229 residues), 228.5 bits, see alignment E=1e-71 PF07971: Glyco_hydro_92" amino acids 264 to 740 (477 residues), 578.8 bits, see alignment E=9.8e-178

Best Hits

KEGG orthology group: None (inferred from 71% identity to zpr:ZPR_2731)

MetaCyc: 62% identical to alpha-1,2-mannosidase (Bacteroides thetaiotaomicron)
3.2.1.-; 3.2.1.-

Predicted SEED Role

"Alpha-1,2-mannosidase" in subsystem Mannose Metabolism

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z7B1 at UniProt or InterPro

Protein Sequence (762 amino acids)

>CA265_RS16240 alpha-mannosidase (Pedobacter sp. GW460-11-11-14-LB5)
MKRLFIALLSVAASTSFAQTIGKITDPVDWINPLMGTASKPSLSNGNTYPAIGLPWGMNM
WTPQTGKNGDGWAYVYDADKIRGFKQTHQPSPWMNDYGAFALMPVTGKLKFTDDERASWF
SHKAEVSKPYYYSVYLADADVTTEITPTERAAQFRFTFPKTDSAYVVVDAQNKGSYIKII
PAERKIIGYTTKYARGPLPKNFKNYFVIYFNKDFKLAKTWDDKKLNDKDLELTVDHAGAV
IGFATQKGEQVIAKVASSFISFEQADLNLKRELANDGFDATKAKGRATWNKTLSKIAVEG
GTIDQTRTFYSAMYRTLFFPNKLYEIDAQNQIVHWSPYNGQVLPGYMFAGTGFWDTFRAL
YPFLNLVYPSINKEMQQGLINDYKEGGWLPEWSSPGYANIMVGNNSASVVSDAYIKGMRG
YDIETLWQAVKHGANNEGPMEAVGRDGVKYYNELGYVPFDVKKNENAAKTLEYSYDDFTI
YQLGRALGKPASEIDIYKKRAMNYKNLFDPASGLMRGKNQDGTFQSPFSPFKWGGAFTEG
NSWHYTWSVFQDVDGLARLMGGHSKFVTKLDSVFAMPPVFDESAYGGVIHEIREMQIANM
GQYAHGNQPIQHMIYLYNYGGAPYKTQYWVRETMNRMYKATPDGYCGDEDNGQTSAWYVF
SAMGFYPVTPAVDQYVLGAPLFKKVTITLENGKTVVVNAAANSDNNRYVQSLQMNGKAYS
KNWISHSGLQKGAVLNFNMTATPNKTRGSNPADFPYSLSTEK