Protein Info for CA265_RS15930 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: uroporphyrinogen decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01208: URO-D
  • amino acids 1 to 339 (339 residues), 406 bits, E=6.4e-126
• TIGR01464: uroporphyrinogen decarboxylase
  • amino acids 6 to 338 (333 residues), 411.1 bits, E=1.7e-127

Best Hits

Swiss-Prot: 47% identical to DCUP_PARUW: Uroporphyrinogen decarboxylase (hemE) from Protochlamydia amoebophila (strain UWE25)

KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 91% identity to phe:Phep_3444)

MetaCyc: 40% identical to uroporphyrinogen decarboxylase (Escherichia coli K-12 substr. MG1655)
Uroporphyrinogen decarboxylase. [EC: 4.1.1.37]

Predicted SEED Role

"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)

MetaCyc Pathways

• superpathway of heme b biosynthesis from glutamate (9/10 steps found)
• superpathway of heme b biosynthesis from glycine (6/8 steps found)
• heme b biosynthesis I (aerobic) (3/4 steps found)
• heme b biosynthesis II (oxygen-independent) (3/4 steps found)
• heme b biosynthesis V (aerobic) (3/4 steps found)
• superpathway of heme b biosynthesis from uroporphyrinogen-III (4/6 steps found)
• heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (3/9 steps found)
• 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (3/9 steps found)
• superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.37

Sequence Analysis Tools

See A0A1X9Z7P4 at UniProt or InterPro

Protein Sequence (341 amino acids)

>CA265_RS15930 uroporphyrinogen decarboxylase (Pedobacter sp. GW460-11-11-14-LB5)
MKNNLFLDAAFSKQTERPPVWMMRQAGRFMPQYWEIKNKYSFLEMCKTPEIAADVTMLPV
DLLDIDAAILFCDILVTGEAMGGDLSFTQGVGPKFANPVRTANDIENLNVDCLDELQYVA
DAIKVIQQRLDSRIPLIGFAGAPFTVMSYLIEGGSSKDFKLTKLFIHNQPELAHKLLAKI
AKVTADYLNLQIAAGVNAVQIFDSWALALSWNDYQEFSHRYIQEIIANLNRKDIPVISFC
KGSSVFAPIMAEAKPDVISVDWNADLLNIKNALPAGIAVQGNLDPHILYADKAVIKAQIH
KLFERLRGTEGFIFNLGHGIMPDIPFDNVKYAIEVVKEFRY