Protein Info for CA265_RS14995 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: sodium-translocating pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 748 transmembrane" amino acids 7 to 29 (23 residues), see Phobius details amino acids 59 to 79 (21 residues), see Phobius details amino acids 90 to 112 (23 residues), see Phobius details amino acids 137 to 164 (28 residues), see Phobius details amino acids 252 to 267 (16 residues), see Phobius details amino acids 282 to 303 (22 residues), see Phobius details amino acids 315 to 335 (21 residues), see Phobius details amino acids 355 to 377 (23 residues), see Phobius details amino acids 398 to 423 (26 residues), see Phobius details amino acids 428 to 449 (22 residues), see Phobius details amino acids 494 to 519 (26 residues), see Phobius details amino acids 526 to 548 (23 residues), see Phobius details amino acids 594 to 612 (19 residues), see Phobius details amino acids 617 to 635 (19 residues), see Phobius details amino acids 689 to 711 (23 residues), see Phobius details TIGR01104: V-type H(+)-translocating pyrophosphatase" amino acids 10 to 708 (699 residues), 898.5 bits, see alignment E=1.9e-274 PF03030: H_PPase" amino acids 17 to 701 (685 residues), 898.4 bits, see alignment E=1.6e-274

Best Hits

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 87% identity to phe:Phep_1001)

Predicted SEED Role

"Pyrophosphate-energized proton pump (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.1

Use Curated BLAST to search for 3.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z6X3 at UniProt or InterPro

Protein Sequence (748 amino acids)

>CA265_RS14995 sodium-translocating pyrophosphatase (Pedobacter sp. GW460-11-11-14-LB5)
MDFLQNNLIYCIPALGLVGIIVMMIKSAWVNKQDAGDKNMQELAGYIADGAMAFLKAEWR
VLSIFAVFTAALLAYSGTITEIKGVPMHSSWIISISFIIGAVFSATAGYIGMKSATKANV
RTTQAARTSLKQALKVSFTGGTVMGLGVAGLAVLGLGGLFIVFLKHFNVVSVNSVEMKTA
IEVLTGFSLGAESIALFARVGGGIYTKAADVGADLVGKVEAGIPEDDVRNPATIADNVGD
NVGDVAGMGADLFGSYVATILATMVLGQEIDVKDNFGGMSPILLPMVICGLGIIFSIIGT
WFVTIKDEKSNVQTALNLGNWSSILITAVASFFIVKWMLPETLNLRGYEFSSINVFYAII
VGLVVGTIMSLVTEYFTAMGKGPVNSIIQQSSTGHATNIIAGLAVGMKSTVIPILVLAGG
IMLSYHFAGLYGVAIAAAGMMATTAMQLAIDAFGPIADNAGGIAEMSQLPPEVRERTDNL
DAVGNTTAATGKGFAIASAALTSLALFAAFVGIAGITAIDIYKAPVLAGLFVGGMIPFIF
SALCIQAVGKAAMDMVQEVRRQFREIPGIMEYKAKPEYEKCVAISTKASIREMMMPGAIA
LITPIIVGFTFGPEVLGGLLAGVTVTGVLMGIFQSNAGGAWDNAKKSFEQGVMINGEMHY
KKSEPHKASVTGDTVGDPFKDTSGPSMNILIKLMSIVSLVIAPYIAVKAIAGEHKLEVRK
EIRIEQKTDSLGHNIADTLINTTDTLSR