Protein Info for CA265_RS12775 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: ATP-dependent chaperone ClpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 866 TIGR03346: ATP-dependent chaperone protein ClpB" amino acids 6 to 860 (855 residues), 1310.6 bits, see alignment E=0 PF02861: Clp_N" amino acids 17 to 68 (52 residues), 35.4 bits, see alignment 6.2e-12 amino acids 92 to 143 (52 residues), 43.5 bits, see alignment 1.8e-14 PF00004: AAA" amino acids 201 to 333 (133 residues), 47.8 bits, see alignment E=1.4e-15 amino acids 600 to 718 (119 residues), 30.8 bits, see alignment E=2.3e-10 PF17871: AAA_lid_9" amino acids 341 to 441 (101 residues), 121.3 bits, see alignment E=1e-38 PF07724: AAA_2" amino acids 594 to 764 (171 residues), 235.8 bits, see alignment E=1.8e-73 PF00158: Sigma54_activat" amino acids 598 to 715 (118 residues), 27.2 bits, see alignment E=1.9e-09 PF07728: AAA_5" amino acids 599 to 719 (121 residues), 49.2 bits, see alignment E=3.8e-16 PF10431: ClpB_D2-small" amino acids 771 to 850 (80 residues), 92.6 bits, see alignment E=8.5e-30

Best Hits

Swiss-Prot: 68% identical to CLPB_BACTN: Chaperone protein ClpB (clpB) from Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)

KEGG orthology group: K03695, ATP-dependent Clp protease ATP-binding subunit ClpB (inferred from 70% identity to coc:Coch_1859)

Predicted SEED Role

"ClpB protein" in subsystem Protein chaperones or Proteolysis in bacteria, ATP-dependent

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z5K9 at UniProt or InterPro

Protein Sequence (866 amino acids)

>CA265_RS12775 ATP-dependent chaperone ClpB (Pedobacter sp. GW460-11-11-14-LB5)
MNFNNFTIKAQEAVQQASEIAQGNQQQAIETAHLLKGLLTVDENVVSYVLKKLNVNLNSL
NQNLDAEIAKFPKVSGSNVYLSSNANSVLQKAQTFLKEFKDEFVSVEHLLLGILAVNDST
SKLLKEQGVNEKDLKKAIVELRGDNRVTDQNAEATYQALSKYARNLNEYAESGKLDPVIG
RDEEIRRVIQILSRRTKNNPILIGEPGVGKTAIAEGIAFRIIKGDVPENLKSKVVYSLDM
GSLIAGAKYKGEFEERLKAVVKEVTQSDGDIILFIDEIHTLVGAGGGEGAMDAANILKPA
LARGELRAIGATTLDEYQKYLEKDKALERRFQKVMVEEPDTQDAISILRGLKERYETHHK
VRIKDEAIIAAVEMSQRYISDRFLPDKAIDLMDEAASKLRMEMDSVPENVDALDREIMRL
EIEREAIKREKDDRKVKELSEEIANLSAERDEFKAKWQGEKDLVDAVNNELEQIEHYKLE
AEQAERAGDYGKVAEIRYGKIKEAQDKVEKLKADLESQQSDSRMLKEEVTADDIAGVVGR
WTGIPVTKLIASEREKLLHLEEELHQRVAGQDEAIEAISDAIRRSRAGLQDKRKPIGSFI
FLGTTGVGKTELAKALAEFLFNDENALTRIDMSEYQERHAVSRLIGAPPGYVGYDEGGQL
TEAVRRKPYSVVLLDEIEKAHPDVFNILLQVLDDGRLTDNKGRTVNFKNTIIIMTSNIGA
HLIQDNFKNLSDENREEVIAKTKNELFEVLKQTIRPEFLNRIDELIMFTPLNRSEIRNIV
SLQFKHVQQTLAEMGIEMDASDEALDWLAQLGYDPQFGARPLKRVIQKRILNELSKEILA
GKIDKDSKIKLDMFDHNFVFLNQNAG