Protein Info for CA265_RS10080 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: acetate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00016: acetate kinase
  • amino acids 1 to 394 (394 residues), 497.9 bits, E=9.2e-154
• PF00871: Acetate_kinase
  • amino acids 3 to 390 (388 residues), 498 bits, E=7.9e-154

Best Hits

Swiss-Prot: 58% identical to ACKA_FLAJ1: Acetate kinase (ackA) from Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101)

KEGG orthology group: K00925, acetate kinase [EC: 2.7.2.1] (inferred from 58% identity to cao:Celal_3042)

MetaCyc: 50% identical to acetate kinase monomer (Clostridium acetobutylicum ATCC 824)
Acetate kinase. [EC: 2.7.2.1, 2.7.2.15]

Predicted SEED Role

"Acetate kinase (EC 2.7.2.1)" in subsystem Ethanolamine utilization or Fermentations: Lactate or Fermentations: Mixed acid or Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate or Threonine anaerobic catabolism gene cluster (EC 2.7.2.1)

MetaCyc Pathways

• Bifidobacterium shunt (12/15 steps found)
• pyruvate fermentation to acetate II (3/3 steps found)
• superpathway of acetate utilization and formation (3/3 steps found)
• L-threonine degradation I (5/6 steps found)
• acetate and ATP formation from acetyl-CoA I (2/2 steps found)
• mixed acid fermentation (12/16 steps found)
• superpathway of N-acetylneuraminate degradation (16/22 steps found)
• pyruvate fermentation to acetate and (S)-lactate I (3/4 steps found)
• pyruvate fermentation to acetate I (2/3 steps found)
• pyruvate fermentation to acetate IV (2/3 steps found)
• pyruvate fermentation to acetate VII (2/3 steps found)
• glycine degradation (reductive Stickland reaction) (1/2 steps found)
• (S)-propane-1,2-diol degradation (3/5 steps found)
• acetylene degradation (anaerobic) (3/5 steps found)
• ethanolamine utilization (3/5 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (13/19 steps found)
• pyruvate fermentation to acetate and lactate II (2/4 steps found)
• superpathway of L-threonine metabolism (12/18 steps found)
• acetyl-CoA fermentation to butanoate (4/7 steps found)
• reductive glycine pathway of autotrophic CO₂ fixation (5/9 steps found)
• superpathway of Clostridium acetobutylicum acidogenic fermentation (5/9 steps found)
• lactate fermentation to acetate, CO₂ and hydrogen (Desulfovibrionales) (4/8 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• methanogenesis from acetate (2/6 steps found)
• (S)-lactate fermentation to propanoate, acetate and hydrogen (7/13 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (4/9 steps found)
• superpathway of L-alanine fermentation (Stickland reaction) (3/9 steps found)
• L-lysine fermentation to acetate and butanoate (3/10 steps found)
• gallate degradation III (anaerobic) (3/11 steps found)
• purine nucleobases degradation I (anaerobic) (5/15 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (6/17 steps found)
• superpathway of methanogenesis (2/21 steps found)
• superpathway of L-lysine degradation (7/43 steps found)

KEGG Metabolic Maps

• Propanoate metabolism
• Pyruvate metabolism
• Taurine and hypotaurine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.2.1 or 2.7.2.15

Sequence Analysis Tools

See A0A1X9Z485 at UniProt or InterPro

Protein Sequence (398 amino acids)

>CA265_RS10080 acetate kinase (Pedobacter sp. GW460-11-11-14-LB5)
MNILVINSGSSSLKYQLFNMPEKAPLCSGLVERIGIEGSFIKHSVYRNNEKYNIEQSGFI
ANHGEGLKQVLALLTEGEYAVIASPDDIAAVGHRVVHGGEHFTGATLITDEVKHQIKKLF
SLAPLHNPVNYKCIEVAEQTFVNAKQIAVFDTAFHQTIPEQAYRYAIPEWYYKEHGIRVY
GFHGTSHKYVSEQAIKWLNKAESKIISIHLGNGCSITAIKNGKSIDTSMGFGPLSGLMMG
TRSGDIDPSVIFHLMEHSGYTLEQLSTLVNKQSGLLGVGGSSDMRDIRKMVSEGNAAAIL
ALKLYAYRIKKFIGAYAAILNGIDAIVFTAGVGENDSNMREAVCSALDYLGIELDPNQNA
AYHGALKEINKTGAKVKILVIPTNEEYEIAHQCFERLT