Protein Info for CA265_RS09630 in Pedobacter sp. GW460-11-11-14-LB5
Annotation: acyl-CoA dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 56% identical to GCDH_PIG: Glutaryl-CoA dehydrogenase, mitochondrial (Fragment) (GCDH) from Sus scrofa
KEGG orthology group: K00252, glutaryl-CoA dehydrogenase [EC: 1.3.99.7] (inferred from 91% identity to phe:Phep_2329)MetaCyc: 57% identical to glutaryl-CoA dehydrogenase (Pseudomonas putida KT2440)
GLUTARYL-COA-DEHYDROGENASE-RXN [EC: 1.3.8.6]
Predicted SEED Role
"Glutaryl-CoA dehydrogenase (EC 1.3.99.7)" (EC 1.3.99.7)
MetaCyc Pathways
- glutaryl-CoA degradation (3/5 steps found)
- L-tryptophan degradation III (eukaryotic) (5/15 steps found)
- crotonate fermentation (to acetate and cyclohexane carboxylate) (3/16 steps found)
- benzoate fermentation (to acetate and cyclohexane carboxylate) (3/17 steps found)
- toluene degradation VI (anaerobic) (3/18 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.3.99.7
Use Curated BLAST to search for 1.3.8.6 or 1.3.99.7
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9Z3S1 at UniProt or InterPro
Protein Sequence (396 amino acids)
>CA265_RS09630 acyl-CoA dehydrogenase (Pedobacter sp. GW460-11-11-14-LB5) MSKSAKKDLYEAPDYYLLDELLTDEHKLIRATARDWVKKEVSPIIEDYAQKAEFPKHLIK GLADIGAFGPTIPVEYGGAGLDYTAYGILMQEIERGDSGIRSTASVQGSLVMYPIYAYGS EEQRKKYLPKLASGEMMGCFGLTEPDHGSNPGGMVTNIKDAGSHYILNGAKMWISNAPFA DIAVVWAKDESGKIRGLIVERGMEGFSTPETHHKWSLRASATGELVFDNVKVPKENIFPE ISGLKGPLGCLNQARYGIAWGALGAAMDCYDTALRYSKERVQFGKPIGGFQLQQKKLAEM VTEITKGQLLVWRLGVLKSENRASAEQISMAKRNSVEIALDIARNARQMLGGMGITGEYS IMRHMMNLESVVTYEGTHDIHLLITGMDVTGLNAFK