Protein Info for CA265_RS08885 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: replicative DNA helicase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 520 PF00772: DnaB" amino acids 31 to 131 (101 residues), 105.3 bits, see alignment E=2.4e-34 TIGR00665: replicative DNA helicase" amino acids 31 to 473 (443 residues), 539.3 bits, see alignment E=3.3e-166 PF03796: DnaB_C" amino acids 206 to 471 (266 residues), 353.6 bits, see alignment E=8.8e-110 PF13481: AAA_25" amino acids 216 to 386 (171 residues), 34.2 bits, see alignment E=3.1e-12

Best Hits

KEGG orthology group: K02314, replicative DNA helicase [EC: 3.6.4.12] (inferred from 84% identity to phe:Phep_2060)

Predicted SEED Role

"Replicative DNA helicase (EC 3.6.1.-)" in subsystem DNA-replication (EC 3.6.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.-, 3.6.4.12

Use Curated BLAST to search for 3.6.1.- or 3.6.4.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z3G0 at UniProt or InterPro

Protein Sequence (520 amino acids)

>CA265_RS08885 replicative DNA helicase (Pedobacter sp. GW460-11-11-14-LB5)
MSIDNEQGGKNSMTARKSRLSNTISSQGKIPPQALDLEEAVLGALMLEKDALSAVIDVLK
PEVFYNIAHQKIFEAIHILFQKSRPVDILTVTAELRTLGTLEIVGGAYYITNLTNRVASA
ANIEFHARIISQKYIQRELIRISTEIITNAYEDTTDIFDLLDQAEKGLFEIAQNNLRRDT
QKMDDIIKQSLATLEELRTKTDGLTGVPTGFTGLDRITGGWQKQDLVIIAARPAMGKTAF
VLTCARNATVDFAKPTVVFSLEMSSVQLVNRLISGEAEIEQEKIRKGNLQEWEWQQLHSK
IGRLTEAPLLIDDTPALNIFEFRAKCRRLKSQYDIQLVIVDYLQLMHGKGEGKGGGNREQ
EIGSISRALKSVAKELDVPVLALSQLSRAVESRPGLQGKRPMLSDLRESGSIEQDADMVL
FLYRPEYYGITEDEQGRSQAGIGEVIIAKHRNGETGIVPLKFVGKFVKFQDLEDDFNAPP
NSFAADPSAGMYPSQDFEKQSNVIIRPSKMDDYNDDDPPF