Protein Info for CA265_RS07560 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: DNA polymerase III subunit epsilon

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 457 TIGR00573: exonuclease, DNA polymerase III, epsilon subunit family" amino acids 3 to 169 (167 residues), 91.4 bits, see alignment E=2.8e-30 PF00929: RNase_T" amino acids 5 to 157 (153 residues), 106.7 bits, see alignment E=1.9e-34 PF01541: GIY-YIG" amino acids 199 to 268 (70 residues), 34.5 bits, see alignment E=2.1e-12

Best Hits

KEGG orthology group: K02342, DNA polymerase III subunit epsilon [EC: 2.7.7.7] (inferred from 62% identity to phe:Phep_2656)

Predicted SEED Role

"DNA polymerase III epsilon subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z3L4 at UniProt or InterPro

Protein Sequence (457 amino acids)

>CA265_RS07560 DNA polymerase III subunit epsilon (Pedobacter sp. GW460-11-11-14-LB5)
MLYAVVDIETTGGHASANGITEVAINIHDGNQIVESYTTLINPKQAIPAYITALTGIDDH
MLMDAPTFDDVALQIYQLLNDKIFVAHNVNFDYSFLKHHLAAAGYDLQCKKLCTVRLSRK
LIPGKSSYSLGKLCTALQIPIQNRHRAAGDADATSILFNLLLEHDQEGTIAEMLKKTSKE
QVLPPHLDKACILRLPNQPGVYYFKDSKGKIIYVGKAKNLKKRVTSHFTGNTPNRQRQDF
LRTIHHVDYVICGTELMALILEANEIKRLWPENNRAMKRYEHKYDLYVFEDQNGYLRLAI
DKHKKNNNALQSFNSLLEGYNFLNQLVDKYQLCAKLCYLQKTATKCYAHENGQCFGACSG
IETVAVYNKKLNAALSDIQNQQPSFALVDEGRKEEEFSCLVVEKGKFYGMGYFTDKNYLS
DGLAPIKNDLSIYPSNSYILNLILNYAEQHPQKLYKL