Protein Info for CA265_RS07420 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: CTP synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00337: CTP synthase
  • amino acids 1 to 528 (528 residues), 796.8 bits, E=4.5e-244
• PF06418: CTP_synth_N
  • amino acids 3 to 267 (265 residues), 425.1 bits, E=1.6e-131
• PF00117: GATase
  • amino acids 303 to 527 (225 residues), 142.1 bits, E=2.6e-45
• PF07722: Peptidase_C26
  • amino acids 368 to 510 (143 residues), 30.6 bits, E=4.3e-11

Best Hits

Swiss-Prot: 76% identical to PYRG_CYTH3: CTP synthase (pyrG) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K01937, CTP synthase [EC: 6.3.4.2] (inferred from 88% identity to phe:Phep_2586)

MetaCyc: 56% identical to CTP synthetase (Bacillus subtilis subtilis 168)
CTP synthase. [EC: 6.3.4.2]

Predicted SEED Role

"CTP synthase (EC 6.3.4.2)" (EC 6.3.4.2)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• L-glutamate and L-glutamine biosynthesis (7/7 steps found)
• superpathway of pyrimidine ribonucleosides salvage (9/10 steps found)
• superpathway of pyrimidine ribonucleotides de novo biosynthesis (8/9 steps found)
• superpathway of pyrimidine nucleobases salvage (4/4 steps found)
• UTP and CTP de novo biosynthesis (3/3 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (3/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (3/4 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Pyrimidine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.2

Sequence Analysis Tools

See A0A1X9Z2V7 at UniProt or InterPro

Protein Sequence (538 amino acids)

>CA265_RS07420 CTP synthetase (Pedobacter sp. GW460-11-11-14-LB5)
MTKYIFVTGGVTSSLGKGIISASLAKLLQARGYRVTIQKFDPYINIDPGTLNPYEHGECF
VTEDGAETDLDLGHYERFLNVPTSQANNITTGRIYQNVINKERKGEYLGKTVQVVPHITD
EIKRNMRILGDSGEYDIVITELGGTVGDIESLPFIEAVRQFKWEEGSTNAIVIHLTLVPY
LAAAGELKTKPTQHSVKALLEYGIQPDILVCRTEHHISPEIRKKIALFCNVNINAVVESM
DASTIYDVPLLMLKEQLDKTVLSKLKLPTKSDPDMESWKDFLGRLKNPTAEVRIGLIGKY
VELPDAYKSIIESFVHAGSKNECKVKVEYIHSEGIFPDNVKDKLGHLQGVLVAPGFGSRG
IEGKIDAIKYVRENNVPFFGICLGMQCAVIEFGRNVLGLKDAHTTEIEENAANPVINMME
EQKKITNKGGTMRLGSYPCDIKKGTKAFSIYGKSHINERHRHRYEFNNDYLKQYEDAGMI
ASGMNPQTNLVEIVELKNHPFFVGGQFHPELKSTVANPHPLFVKFVAAAMEFAKKKTN