Protein Info for CA265_RS07170 in Pedobacter sp. GW460-11-11-14-LB5
Annotation: beta-glucuronidase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K01195, beta-glucuronidase [EC: 3.2.1.31] (inferred from 53% identity to fjo:Fjoh_4198)Predicted SEED Role
"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)
MetaCyc Pathways
- superpathway of hexuronide and hexuronate degradation (10/10 steps found)
- superpathway of β-D-glucuronosides degradation (7/7 steps found)
- β-D-glucuronide and D-glucuronate degradation (3/3 steps found)
- lactose degradation III (1/1 steps found)
- luteolin triglucuronide degradation (3/4 steps found)
- xyloglucan degradation II (exoglucanase) (5/8 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (18/31 steps found)
KEGG Metabolic Maps
- Drug metabolism - other enzymes
- Flavone and flavonol biosynthesis
- Galactose metabolism
- Glycosaminoglycan degradation
- Glycosphingolipid biosynthesis - ganglio series
- Other glycan degradation
- Pentose and glucuronate interconversions
- Porphyrin and chlorophyll metabolism
- Sphingolipid metabolism
- Starch and sucrose metabolism
Isozymes
Compare fitness of predicted isozymes for: 3.2.1.23
Use Curated BLAST to search for 3.2.1.23 or 3.2.1.31
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9Z355 at UniProt or InterPro
Protein Sequence (609 amino acids)
>CA265_RS07170 beta-glucuronidase (Pedobacter sp. GW460-11-11-14-LB5) MLKTTYSVFLICFSLLSSISYGQVTAIQNIQARKIQSLNGKWNYIVDPYENGYYDYRHEP FDQSKTGTGGYFDDKVQKDKSELIEYDFDHSPQMNVPGDWNSQSEKLELYEGNVWLRKKF DAKPEKGKKYFVYFGAVNYEAHVYLNGKKLGVHKGGFTPFQFDVTSNLKVGENSIVLKVD NIRKQDEIPTVNTDWWNYGGITRDVFLAEFPEHFISDYKLQLVKGNNNLLNFSVKLADAT AGQEITLSIPELKLEKKYKTDGEGKIADEFTWNNLSLWSPETPKLYAVNIKTDKENINDK IGFRTIQVEGDSILLNGKSVFLRGISLHDENPLLAGRLRSEGDMRMMLQWAKDMNCNYVR LAHYPHNEEMIRLADEMGLLVWAEVPVYWTISWTNPATYANAKKQLTDLIVRDKNRASVI VWSIGNETPLSDARLSFMSNLAETARSLDDTRLVAAALEVHREGNNIILNDPLGEKIDLV SFNEYAGWYWGGNPSEITKYNFDIKYKKPVVITEFGGDALGGFHADENTRWSEEYQEALY KNQIAMLSKIGALRGMTPWILTDFRSPRRQHPIYQNFWNRKGLISETGKKKKAFFVLKDF YDQMQVKYK