Protein Info for CA265_RS06550 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: DNA polymerase III subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1004 PF02811: PHP" amino acids 3 to 112 (110 residues), 54 bits, see alignment E=5.4e-18 TIGR00594: DNA polymerase III, alpha subunit" amino acids 184 to 948 (765 residues), 471.5 bits, see alignment E=3.3e-145 PF07733: DNA_pol3_alpha" amino acids 268 to 506 (239 residues), 215.5 bits, see alignment E=2.1e-67 PF17657: DNA_pol3_finger" amino acids 514 to 678 (165 residues), 128.3 bits, see alignment E=3.7e-41 PF14579: HHH_6" amino acids 751 to 837 (87 residues), 60.3 bits, see alignment E=3.4e-20

Best Hits

Predicted SEED Role

"DNA polymerase III alpha subunit (EC 2.7.7.7)" in subsystem DNA-replication (EC 2.7.7.7)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.7

Use Curated BLAST to search for 2.7.7.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z2I8 at UniProt or InterPro

Protein Sequence (1004 amino acids)

>CA265_RS06550 DNA polymerase III subunit alpha (Pedobacter sp. GW460-11-11-14-LB5)
MFLNVHSSYSLKYGTLNIEQLIATARNLGIHQMVLTDINNSTGAVEFIRECYKQGIAKEA
DEIHKGNIPYQIKPVAGIEFRVDHKLLYVGVAKNREGMRELNEFLSHHNINHIPLPQIPP
EMENVYIIYPFQKSFNTVLKGNEFIGIRAKQLNLLYKHPLLKQKEKLLVWHPVTISDKIT
YRLHQYLRAIELNTLLTKVPDEQKCDPDEFLIPEVELTQQFEQYPFIVQNTQRLLNSCDL
SVYFEDGPAPVSKNKFFYTGDFEGDKKMLRELAEEGLRYRYGENNTEAIERLEKELRIIE
LKNFCAYFLITYDIVRYAMTECGFYHVGRGSGANSIVAYCLRITDVDPIDLDLYFERFLH
EKRTSPPDFDIDFSWDEREVIQRYIFERYPKWHVAFLGTMSTFKDRAIIREIGKVLGLPK
GEIDSFTDPTKERENLLNATYQKLLAVYQYMKGMPNQRSIHAGGILISEEPITYYTALDM
PPKGFPTVQWDMYEAEAIGYEKFDILSQRGIGHIREAVQLIKKNKAKDIDIHDFKTFKND
QKLNGILKEGQPIGCFYIESPAMRQLLKKLKCDNYLTLVAASSIIRPGVASSGMMKAYIE
RYHAPEKVVYLCEVMKQRLSETYGVMVYQEDVIKVCHYFAGLDLADADVLRKAMSGKYRS
KLAFDELVNKFFASARKEGHSEELITEVWRQISSFAGYSFSKAHSASFAVESYQSLYLKT
YYPMEFMVAVLNNYGGFYSRWVYVHELQKTGARVHLPCVNHSDDVVNIKGEDAYLGFIAV
QGLEEKNIKIIPAERHTNGLYIDLEDFVKRTCISLEQAIILIRLGALRFTGKDRKTLLWD
VHNYLGFKQKKVNHAELFKLSYKTYQLPELADSELENAYTELELLGYPLNYDMFDFLKTP
YRGDTMAADMHKHLGKTVRMVGNYVCEKTVHTIKNTKMWFGTFLDANGDFFDTTHFPNTT
PMYPFKGKGCYLILGKVVEDFGFQSIEVLKFAKLDIQMNPVAID