Protein Info for CA265_RS05705 in Pedobacter sp. GW460-11-11-14-LB5
Annotation: aldehyde dehydrogenase (NADP(+))
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K14519, NADP-dependent aldehyde dehydrogenase [EC: 1.2.1.4] (inferred from 55% identity to dfe:Dfer_2501)Predicted SEED Role
"Ketoglutarate semialdehyde dehydrogenase (EC 1.2.1.26)" in subsystem D-Galacturonate and D-Glucuronate Utilization or Proline, 4-hydroxyproline uptake and utilization (EC 1.2.1.26)
MetaCyc Pathways
- cytosolic NADPH production (yeast) (4/5 steps found)
- superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
- trans-4-hydroxy-L-proline degradation II (3/4 steps found)
- pyruvate fermentation to acetate VIII (1/2 steps found)
- mitochondrial NADPH production (yeast) (3/5 steps found)
- D-galactarate degradation II (1/3 steps found)
- D-glucarate degradation II (1/3 steps found)
- L-carnitine degradation II (1/3 steps found)
- L-lyxonate degradation (1/3 steps found)
- D-glucuronate degradation II (2/5 steps found)
- 1,2-dichloroethane degradation (1/4 steps found)
- D-arabinose degradation III (2/6 steps found)
- L-arabinose degradation III (2/6 steps found)
- D-galacturonate degradation II (1/5 steps found)
- D-xylose degradation III (1/5 steps found)
- D-xylose degradation V (1/5 steps found)
- superpathway of microbial D-galacturonate and D-glucuronate degradation (18/31 steps found)
- superpathway of pentose and pentitol degradation (12/42 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.26 or 1.2.1.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A1X9Z2M2 at UniProt or InterPro
Protein Sequence (528 amino acids)
>CA265_RS05705 aldehyde dehydrogenase (NADP(+)) (Pedobacter sp. GW460-11-11-14-LB5) MNGQNIVASTYIEVNERSLKAVNPATGLTLDGDFFKASERLVDDALTSATLAFQSYRNLN KDLKAAFLNAIADEIANLGEELVNRASAESGLPLGRLQGELGRTTGQLRLFANLVAEGSW VDAIIDTALPERQPLPRPDIRRMLIPIGPVVVFGASNFPLAFSVAGGDTASALASGCPVV VKAHPAHYGTSALVGGAIIKAAEKTGMPKGVFSLLYDDGYTIGAGLVQHPLTKAVTFTGS FKGGMALINLAQQREQPIPVFAEMGSINPVIFLPKAIENQAEELAKKYAASITLGAGQFC TNPGLLLAVQSPALESFKAALKEAISTIPSATMLTEGIASNYGKLSAEVVNEGGVALLSA STVKNTELQNQSEAKIAQVSAADFIKNPKLREEIFGPYSLLVVAQDIAELEKAIDVLEGQ LTVTLMAEKQELQGYQTLVNKLTDKTGRIILNGVPTGVEVCAAMQHGGPFPATNDSRFTS VGSTAINRFARPLAYQDWEQELLPDELKDGNPLGIFRTINQKLTKSHE