Protein Info for CA265_RS02975 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: threonylcarbamoyl-AMP synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 188 TIGR00057: tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family" amino acids 4 to 178 (175 residues), 156.4 bits, see alignment E=2.8e-50 PF01300: Sua5_yciO_yrdC" amino acids 11 to 188 (178 residues), 159.2 bits, see alignment E=3.8e-51

Best Hits

Swiss-Prot: 32% identical to TSAC_IDILO: Threonylcarbamoyl-AMP synthase (tsaC) from Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR)

KEGG orthology group: K07566, putative translation factor (inferred from 72% identity to psn:Pedsa_2258)

Predicted SEED Role

"TsaC protein (YrdC domain) required for threonylcarbamoyladenosine t(6)A37 modification in tRNA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z0Y1 at UniProt or InterPro

Protein Sequence (188 amino acids)

>CA265_RS02975 threonylcarbamoyl-AMP synthase (Pedobacter sp. GW460-11-11-14-LB5)
MLRDEINKAFEVLKSGGVILYPTDTIWGLGCDASNPEAVDKLLKIKNRPAEKSLIVLLDV
DSKLQSYVAEIPDVAYDLIEYAENPLTIIFSGAKNLAPNVINADGSVGIRIVKHDFCTPL
IQRFRKPIVSTSANLSGQPSPKFFDDIDAEIIDAVDYVVDFEQENRTSRKPSTIMKLSPG
GQFEFIRK