Protein Info for CA265_RS01880 in Pedobacter sp. GW460-11-11-14-LB5

Annotation: phosphoglycerate kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 56% identical to PGK_BACMD: Phosphoglycerate kinase (pgk) from Bacillus megaterium (strain DSM 319)

KEGG orthology group: K00927, phosphoglycerate kinase [EC: 2.7.2.3] (inferred from 81% identity to phe:Phep_3335)

MetaCyc: 55% identical to plastidic 3-phosphoglycerate kinase (Spinacia oleracea)
Phosphoglycerate kinase. [EC: 2.7.2.3]

Predicted SEED Role

"Phosphoglycerate kinase (EC 2.7.2.3)" in subsystem Calvin-Benson cycle or Entner-Doudoroff Pathway or Glycolysis and Gluconeogenesis or Glycolysis and Gluconeogenesis, including Archaeal enzymes (EC 2.7.2.3)

MetaCyc Pathways

superpathway of glucose and xylose degradation (16/17 steps found)
gluconeogenesis I (12/13 steps found)
superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (21/26 steps found)
superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (18/22 steps found)
glycolysis II (from fructose 6-phosphate) (10/11 steps found)
glycolysis III (from glucose) (10/11 steps found)
superpathway of glycolysis and the Entner-Doudoroff pathway (14/17 steps found)
glycolysis I (from glucose 6-phosphate) (11/13 steps found)
formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
homolactic fermentation (10/12 steps found)
Bifidobacterium shunt (12/15 steps found)
glycolysis IV (8/10 steps found)
Entner-Doudoroff pathway I (7/9 steps found)
gluconeogenesis III (9/12 steps found)
superpathway of anaerobic sucrose degradation (14/19 steps found)
superpathway of N-acetylneuraminate degradation (16/22 steps found)
heterolactic fermentation (13/18 steps found)
Calvin-Benson-Bassham cycle (9/13 steps found)
sucrose biosynthesis I (from photosynthesis) (6/9 steps found)
hexitol fermentation to lactate, formate, ethanol and acetate (13/19 steps found)
glycolysis VI (from fructose) (7/11 steps found)
superpathway of hexitol degradation (bacteria) (12/18 steps found)
ethene biosynthesis V (engineered) (16/25 steps found)
1-butanol autotrophic biosynthesis (engineered) (17/27 steps found)
glycerol degradation to butanol (9/16 steps found)
oxygenic photosynthesis (9/17 steps found)
photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (15/26 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1X9Z018 at UniProt or InterPro

Protein Sequence (397 amino acids)

>CA265_RS01880 phosphoglycerate kinase (Pedobacter sp. GW460-11-11-14-LB5)
MNTIDQFDFKDKKALIRVDFNVPLDDEFKITDDKRIRAALPTISKILKDGGAVILMSHLG
RPKDGPTDKYSLKHILSDLSALVGVEVKFADDCIGESAVKQAADLKSGEVLLLENLRFYK
EEEKGDVAFAEKLSKLGDVYVNDAFGTAHRAHASTSIIAQFFPDAKYFGYLMASEVENAE
KILNHAERPFTAIMGGAKVSDKILLIEKLLDKVDNLIIGGGMAYTFAKAQGGEIGTSLLE
ADKQELSLELIEKAKAKGVNLILPVDTVIADKFANDADKKDVTSGQIPADWMGLDIGPKS
VALFQDVIKNSKTLLWNGPMGVFEMESFQVGTKAVAEAVVAATKDNGAFSLIGGGDSAAA
IAKFGMEDEVSYVSTGGGALLEYMEGKELPGVKAING